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https://hdl.handle.net/2440/71137
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Type: | Journal article |
Title: | Autoimmune regulator (AIRE)-deficient CD8(+)CD28(low) regulatory T lymphocytes fail to control experimental colitis |
Author: | Pomie, C. Vicente, R. Vuddamalay, Y. Lundgren, B. Van der Hoek, M. Enault, G. Kagan, J. Fazilleau, N. Scott, H. Romagnoli, P. van Meerwijk, J. |
Citation: | Proceedings of the National Academy of Sciences of USA, 2011; 108(30):12437-12442 |
Publisher: | Natl Acad Sciences |
Issue Date: | 2011 |
ISSN: | 0027-8424 1091-6490 |
Statement of Responsibility: | Céline Pomié, Rita Vicente, Yirajen Vuddamalay, Brita Ardesjö Lundgren, Mark van der Hoek, Geneviève Enault, Jérémy Kagan, Nicolas Fazilleau, Hamish S. Scott, Paola Romagnoli and Joost P.M. van Meerwijk |
Abstract: | Mutations in the gene encoding the transcription factor autoimmune regulator (AIRE) are responsible for autoimmune polyendocrinopathy candidiasis ectodermal dystrophy syndrome. AIRE directs expression of tissue-restricted antigens in the thymic medulla and in lymph node stromal cells and thereby substantially contributes to induction of immunological tolerance to selfantigens. Data from experimental mouse models showed that AIRE deficiency leads to impaired deletion of autospecific T-cell precursors. However, a potential role for AIRE in the function of regulatory T-cell populations, which are known to play a central role in prevention of immunopathology, has remained elusive. Regulatory T cells of CD8+CD28low phenotype efficiently control immune responses in experimental autoimmune and colitis models in mice. Here we show that CD8+CD28low regulatory T lymphocytes from AIRE-deficient mice are transcriptionally and phenotypically normal and exert efficient suppression of in vitro immune responses, but completely fail to prevent experimental colitis in vivo. Our data therefore demonstrate that AIRE plays an important role in the in vivo function of a naturally occurring regulatory T-cell population. |
Keywords: | Inflammatory bowel disease suppressor T cells repertoire |
Rights: | Copyright © 2011 by the National Academy of Sciences |
DOI: | 10.1073/pnas.1107136108 |
Published version: | http://dx.doi.org/10.1073/pnas.1107136108 |
Appears in Collections: | Aurora harvest 5 Molecular and Biomedical Science publications |
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