Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/71440
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Spatial analysis of multi-species exclusion processes: Application to neural crest cell migration in the embryonic gut |
Author: | Binder, B. Landman, K. Newgreen, D. Simkin, J. Takahashi, Y. Zhang, D. |
Citation: | Bulletin of Mathematical Biology, 2012; 74(2):474-490 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2012 |
ISSN: | 0092-8240 1522-9602 |
Statement of Responsibility: | Benjamin J. Binder, Kerry A. Landman, Donald F. Newgreen, Johanna E. Simkin, Yoshiko Takahashi, Dongcheng Zhang |
Abstract: | Hindbrain (vagal) neural crest cells become relatively uniformly distributed along the embryonic intestine during the rostral to caudal colonization wave which forms the enteric nervous system (ENS). When vagal neural crest cells are labeled before migration in avian embryos by in ovo electroporation, the distribution of labeled neural crest cells in the ENS varies vastly. In some cases, the labeled neural crest cells appear evenly distributed and interspersed with unlabeled neural crest cells along the entire intestine. However, in most specimens, labeled cells occur in relatively discrete patches of varying position, area, and cell number. To determine reasons for these differences, we use a discrete cellular automata (CA) model incorporating the underlying cellular processes of neural crest cell movement and proliferation on a growing domain, representing the elongation of the intestine during development. We use multi-species CA agents corresponding to labeled and unlabeled neural crest cells. The spatial distributions of the CA agents are quantified in terms of an index. This investigation suggests that (i) the percentage of the initial neural crest cell population that is labeled and (ii) the ratio of cell proliferation to motility are the two key parameters producing the extreme differences in spatial distributions observed in avian embryos. |
Keywords: | Neural crest cells In ovo electroporation Cellular automata model Spatial-point data sets |
Rights: | © Society for Mathematical Biology 2011 |
DOI: | 10.1007/s11538-011-9703-z |
Published version: | http://dx.doi.org/10.1007/s11538-011-9703-z |
Appears in Collections: | Aurora harvest 5 Mathematical Sciences publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.