Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7147
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Type: | Journal article |
Title: | National study of adverse reactions after vaccination with bacille Calmette-Guérin |
Other Titles: | National study of adverse reactions after vaccination with bacille Calmette-Guerin |
Author: | Turnbull, F. McIntyre, P. Achat, H. Wang, H. Stapledon, R. Gold, M. Burgess, M. |
Citation: | Clinical Infectious Diseases, 2002; 34(4):447-453 |
Publisher: | Univ Chicago Press |
Issue Date: | 2002 |
ISSN: | 1058-4838 1537-6591 |
Statement of Responsibility: | F. M. Turnbull, P. B. McIntyre, H. M. Achat, H. Wang, R. Stapledon, M. Gold, and M. A. Burgess |
Abstract: | Few large prospective studies of adverse reactions after bacille Calmette-Guérin (BCG) vaccination are available. In a prospective national study of such adverse reactions among 918 subjects (aged 1 day to 54 years) over a 14-month period, 45 vaccinees (5%) reported 53 adverse reactions (23 injection-site abscesses, 14 severe local reactions, 10 cases of lymphadenitis, and 6 other reactions). Only 1% of vaccinees required medical attention. Reactions, particularly lymphadenitis, were significantly less common in infants <6 months old (but not in subjects aged 6 months) vaccinated by trained (vs. untrained) providers (relative risk [RR], 0.24; 95% confidence interval [CI], 0.090.68). Injection-site abscesses (RR, 2.96; 95% CI, 1.117.90) and severe local reactions (RR, 4.93; 95% CI, 1.1121.90) were significantly more common in older vaccinees. Local reactions were more frequently reported by adult females than by adult males (RR, 7.18; 95% CI, 1.5932.45). Adverse reactions were not significantly associated with any currently available vaccine batch, previous receipt of BCG vaccine, or concomitant administration of other vaccines. |
Keywords: | Humans BCG Vaccine Prospective Studies Adolescent Adult Middle Aged Child Child, Preschool Infant Infant, Newborn Female Male |
Rights: | © 2002 by the Infectious Diseases Society of America |
DOI: | 10.1086/338462 |
Published version: | http://dx.doi.org/10.1086/338462 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
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