Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/71782
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Expression of Toll-like receptors by neonatal leukocytes |
Author: | Dasari, P. Zola, H. Nicholson, I. |
Citation: | Pediatric Allergy and Immunology, 2011; 22(2):221-228 |
Publisher: | Munksgaard Int Publ Ltd |
Issue Date: | 2011 |
ISSN: | 0905-6157 1399-3038 |
Statement of Responsibility: | Pallave Dasari, Heddy Zola & Ian C. Nicholson |
Abstract: | The immune system of neonates is poorly developed; this increases the susceptibility of neonates to infection. For neonates to counter infection effectively, they first need to recognize the presence of pathogens. Toll-like receptors (TLR) are a family of pattern recognition receptors that alert the host to the presence of invading pathogens. To determine whether differences in TLR expression by leukocytes compensate for immunologic immaturity in neonates, TLR expression by monocytes and T lymphocytes from adults and neonates was compared. Expression of TLR1, TLR2, TLR3, TLR4, TLR8 and TLR9 by monocytes and T lymphocytes was detected with antibodies by flow cytometry. TLR1, TLR2, TLR3, TLR4, TLR8 and TLR9 expression by monocytes was detected in adults and neonates. TLR2, TLR3, TLR4, TLR8 and TLR9 expression by T lymphocytes was detected in adults and neonates. Monocytes and T lymphocytes from neonates are capable, like adults, of recognizing the presence of pathogens through TLR. |
Keywords: | Toll-like receptors neonates leukocytes monocytes T lymphocytes |
Rights: | © 2010 John Wiley & Sons A/S |
DOI: | 10.1111/j.1399-3038.2010.01091.x |
Published version: | http://dx.doi.org/10.1111/j.1399-3038.2010.01091.x |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.