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https://hdl.handle.net/2440/7180
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dc.contributor.author | Couper, J. | - |
dc.contributor.author | Steele, C. | - |
dc.contributor.author | Beresford, S. | - |
dc.contributor.author | Powell, T. | - |
dc.contributor.author | McCaul, K. | - |
dc.contributor.author | Pollard, A. | - |
dc.contributor.author | Gellert, S. | - |
dc.contributor.author | Tait, B. | - |
dc.contributor.author | Harrison, L. | - |
dc.contributor.author | Colman, P. | - |
dc.date.issued | 1999 | - |
dc.identifier.citation | Diabetes, 1999; 48(11):2145-2149 | - |
dc.identifier.issn | 0012-1797 | - |
dc.identifier.issn | 1939-327X | - |
dc.identifier.uri | http://hdl.handle.net/2440/7180 | - |
dc.description.abstract | The hypothesis that early exposure to cow's milk or lack of breast-feeding predisposes to type 1 diabetes remains controversial. We aimed to determine prospectively the relationship of, first, duration of exclusive breast-feeding and total duration of breast-feeding, and second, introduction of cow's milk protein as infant formula, cow's milk, or dairy products, to the development of islet antibodies in early life. Some 317 children with a first-degree relative with type 1 diabetes were followed prospectively from birth for 29 months (4-73). Mothers kept a home diary and answered infant feeding questionnaires at 6-month intervals. No systematic feeding advice was given. Insulin autoantibodies (normal range <5.5%), anti-GAD antibodies (<5.0 U), and anti-IA2 antibodies (<3.0 U) were measured at 6-month intervals. Cox proportional hazards model of survival analysis detected no significant difference between children who did not develop islet antibodies (225 of 317 [71%]), children with one islet antibody raised once (52 of 317 [16.4%]), children with one antibody raised repeatedly (18 of 317 [5.7%]), or children with two or more antibodies raised (22 of 317 [6.9%]), in terms of duration of exclusive breast-feeding, total duration of breast-feeding, or introduction of cow's milk-based infant formulas, cow's milk, or dairy products (relative risk: 0.91-1.09). Four of the children with two or more islet antibodies developed type 1 diabetes. We conclude that there is no prospective association between duration of breast-feeding or introduction of cow's milk and the development of islet autoimmunity in high-risk children. | - |
dc.description.statementofresponsibility | Couper, Jennifer J.; Steele, Cheryl; Beresford, Sarah; Powell, Tania; Mccaul, Kieran; Pollard, Angie; Gellert, Shane; Tait, Brian; Harrison, Leonard C.; Colman, Peter G. | - |
dc.language.iso | en | - |
dc.publisher | AMER DIABETES ASSOC | - |
dc.source.uri | http://dx.doi.org/10.2337/diabetes.48.11.2145 | - |
dc.subject | Islets of Langerhans | - |
dc.subject | Milk | - |
dc.subject | Fetal Blood | - |
dc.subject | Animals | - |
dc.subject | Cattle | - |
dc.subject | Humans | - |
dc.subject | Diabetes Mellitus, Type 1 | - |
dc.subject | Glutamate Decarboxylase | - |
dc.subject | Autoantibodies | - |
dc.subject | HLA Antigens | - |
dc.subject | Histocompatibility Testing | - |
dc.subject | Longitudinal Studies | - |
dc.subject | Breast Feeding | - |
dc.subject | Aging | - |
dc.subject | Time Factors | - |
dc.subject | Infant Food | - |
dc.subject | Infant, Newborn | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.title | Lack of association between duration of breast-feeding or introduction of cow's milk and development of islet autoimmunity | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.2337/diabetes.48.11.2145 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Couper, J. [0000-0003-4448-8629] | - |
Appears in Collections: | Aurora harvest Paediatrics publications |
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