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https://hdl.handle.net/2440/71870
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Type: | Conference paper |
Title: | Bone fracture and bone fracture repair |
Author: | Fazzalari, N. |
Citation: | Osteoporosis International, 2011, vol.22, iss.6, pp.2003-2006 |
Publisher: | Springer London Ltd |
Publisher Place: | Sweetapple House Catteshall Road Godalming England GU7 3DJ |
Issue Date: | 2011 |
ISSN: | 0937-941X 1433-2965 |
Conference Name: | Bone Quality Seminars : Osteoporosis International) |
Statement of Responsibility: | N. L. Fazzalari |
Abstract: | Fracture healing is a multistage repair process that involves complex, well-orchestrated steps initiated in response to tissue injury. The early upregulation of IL-6, osteoprotegerin (OPG), VEGF, and BMPs indicates a central role for these factors in the initiation of cartilage and periosteal woven bone formation. In both callus fracture repair and stress fracture repair, the RANKL/OPG ratio is initially reduced, but peaks earlier in stress fracture healing than callus fracture healing. Though the understanding of the biological processes and molecular signals that coordinate fracture repair has advanced, the cause of variability observed in fracture repair is poorly understood. |
Keywords: | Fracture fracture repair microdamage stress |
Rights: | © International Osteoporosis Foundation and National Osteoporosis Foundation 2011 |
DOI: | 10.1007/s00198-011-1611-4 |
Published version: | http://dx.doi.org/10.1007/s00198-011-1611-4 |
Appears in Collections: | Aurora harvest Medical Sciences publications |
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