Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/72833
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Type: | Journal article |
Title: | PI16 is expressed by a subset of human memory Treg with enhanced migration to CCL17 and CCL20 |
Author: | Nicholson, I. Mavrangelos, C. Bird, D. Bresatz-Atkins, S. Eastaff-Leung, N. Grose, R. Gundsambuu, B. Hill, D. Millard, D. Sadlon, T. To, S. Zola, H. Barry, S. Krumbiegel, D. |
Citation: | Cellular Immunology, 2012; 275(1):12-18 |
Publisher: | Academic Press Inc |
Issue Date: | 2012 |
ISSN: | 0008-8749 1090-2163 |
Statement of Responsibility: | Ian C. Nicholson, Christos Mavrangelos, Daniel R.G. Bird, Suzanne Bresatz-Atkins, Nicola G. Eastaff-Leung, Randall H. Grose, Batjargal Gundsambuu, Danika Hill, Debbrah J. Millard, Timothy J. Sadlon, Sarah To, Heddy Zola, Simon C. Barry, Doreen Krumbiegel |
Abstract: | The peptidase inhibitor PI16 was shown previously by microarray analysis to be over-expressed by CD4-positive/CD25-positive Treg compared with CD4-positive/CD25-negative Th cells. Using a monoclonal antibody to the human PI16 protein, we found that PI16-positive Treg have a memory (CD45RO-positive) phenotype and express higher levels of FOXP3 than PI16-negative Treg. PI16-positive Treg are functional in suppressor assays in vitro with potency similar to PI16-negative Treg. Further phenotyping of the PI16-positive Treg revealed that the chemokine receptors CCR4 and CCR6 are expressed by more of the PI16-positive/CD45RO-positive Treg compared with PI16-negative/CD45RO-positive Treg or Th cells. PI16-positive Treg showed enhanced in vitro migration towards the inflammatory chemokines CCL17 and CCL20, suggesting they can migrate to sites of inflammation. We conclude that PI16 identifies a novel distinct subset of functional memory Treg which can migrate to sites of inflammation and regulate the pro-inflammatory response at those sites. |
Keywords: | Regulatory T cells Lymphocyte migration Memory Treg Peptidase inhibitor 16 |
Rights: | Copyright © 2012 Elsevier Inc. All rights reserved. |
DOI: | 10.1016/j.cellimm.2012.04.002 |
Published version: | http://dx.doi.org/10.1016/j.cellimm.2012.04.002 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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hdl_72833.pdf | Accepted version | 610.57 kB | Adobe PDF | View/Open |
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