Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/72835
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Full metadata record
DC Field | Value | Language |
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dc.contributor.author | Weekley, C. | - |
dc.contributor.author | Aitken, J. | - |
dc.contributor.author | Musgrave, I. | - |
dc.contributor.author | Harris, H. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | Biochemistry, 2012; 51(3):736-738 | - |
dc.identifier.issn | 0006-2960 | - |
dc.identifier.issn | 1520-4995 | - |
dc.identifier.uri | http://hdl.handle.net/2440/72835 | - |
dc.description.abstract | The selenoamino acids methylselenocysteine (MeSeCys) and selenomethionine (SeMet) have disparate efficacies as anticancer agents. Herein, we use X-ray absorption spectroscopy to determine the chemical form of selenium in human neuroblastoma cells. Cells treated with MeSeCys contain a significant diselenide component, which is absent from SeMet-treated cells and suggests that metabolites of MeSeCys are capable of altering the redox status of the cells. The differences in the speciation of Se in the selenoamino acid-treated cells may provide insight into the differing anticancer activities of MeSeCys and SeMet. | - |
dc.description.statementofresponsibility | Claire M. Weekley, Jade B. Aitken, Ian F. Musgrave, and Hugh H. Harris | - |
dc.language.iso | en | - |
dc.publisher | American Chemical Society | - |
dc.rights | Copyright © 2012 American Chemical Society | - |
dc.source.uri | http://dx.doi.org/10.1021/bi201462u | - |
dc.subject | Cell Line, Tumor | - |
dc.subject | Humans | - |
dc.subject | Selenium Compounds | - |
dc.subject | Benzene Derivatives | - |
dc.subject | Organoselenium Compounds | - |
dc.subject | Selenocysteine | - |
dc.subject | Cysteine | - |
dc.subject | Antineoplastic Agents | - |
dc.subject | X-Ray Absorption Spectroscopy | - |
dc.title | Methylselenocysteine treatment leads to diselenide formation in human cancer cells: evidence from X-ray absorption spectroscopy studies | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1021/bi201462u | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0985807 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Musgrave, I. [0000-0003-1016-0588] | - |
dc.identifier.orcid | Harris, H. [0000-0002-3472-8628] | - |
Appears in Collections: | Aurora harvest 5 Environment Institute publications IPAS publications |
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