Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7334
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Expression of the costimulator molecules, CD80, CD86, CD28, and CD152 on lymphocytes from neonates and young children |
Author: | Elliott, S. Macardle, P. Roberton, D. Zola, H. |
Citation: | Human Immunology, 1999; 60(11):1039-1048 |
Publisher: | ELSEVIER SCIENCE INC |
Issue Date: | 1999 |
ISSN: | 0198-8859 1879-1166 |
Abstract: | The expression of CD80, CD86, CD28, and CD152 were examined on peripheral blood lymphocytes from adults, neonates (cord blood lymphocytes) and young children (2-20 months of age). There was no difference in the expression of CD80 or CD86 between adult and neonatal B cells, either resting or activated. A higher percentage of resting T cells expressed CD28 in neonates and young children compared to adults. CD28 expression was similar on adult and neonatal T cells activated with PMA and ionomycin. However, CD28 was expressed at greater intensity on a higher percentage of neonatal T cells than adult T cells stimulated with CD3. CD152 expression was lower on neonatal T cells than adult T cells stimulated with PMA and ionomycin and undetectable on neonatal T cells stimulated with CD3. In contrast, intracellular CD152 was equivalent in adult and neonatal T cells stimulated with PMA and ionomycin, suggesting trafficking of CD152 to the cell surface may be differentially regulated in neonatal T cells. Since the T cell response is determined by the balance of signals received from CD28 and CD152, high levels of CD28 expression and lower surface expression of CD152 on neonatal T cells may represent specialisation to promote activation of neonatal T cells. |
Keywords: | B-Lymphocytes Lymphocytes T-Lymphocytes Fetal Blood Humans Tetradecanoylphorbol Acetate Ionomycin Membrane Glycoproteins Antigens, Differentiation Antigens, CD Immunoconjugates Lymphocyte Activation Adult Infant Infant, Newborn CTLA-4 Antigen In Vitro Techniques Abatacept CD3 Complex CD28 Antigens B7-1 Antigen B7-2 Antigen |
DOI: | 10.1016/S0198-8859(99)00090-7 |
Published version: | http://dx.doi.org/10.1016/s0198-8859(99)00090-7 |
Appears in Collections: | Aurora harvest 5 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.