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https://hdl.handle.net/2440/73769
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Type: | Journal article |
Title: | Cortisol-induced increases of plasma oxytocin levels predict decreased immediate free recall of unpleasant words |
Author: | Tops, M. Buisman-Pijlman, F. Boksem, M. Wijers, A. Korf, J. |
Citation: | Frontiers in Psychiatry, 2012; 3(MAY):1-5 |
Publisher: | Frontiers Research Foundation |
Issue Date: | 2012 |
ISSN: | 1664-0640 1664-0640 |
Statement of Responsibility: | Mattie Tops, Femke T. A. Buisman-Pijlman, Maarten A. S. Boksem, Albertus A. Wijers and Jakob Korf |
Abstract: | Cortisol and oxytocin have been shown to interact in both the regulation of stress responses and in memory function. In the present study we administered cortisol to 35 healthy female subjects in a within-subject double-blind placebo-controlled design, while measuring oxytocin levels, adrenocorticotropic hormone (ACTH) levels, and free recall of pleasant and of unpleasant words. We found that cortisol administration suppressed ACTH levels and (1) induced a decrease in oxytocin associated with ACTH suppression and (2) an increase in oxytocin that was independent from ACTH suppression. This cortisol-induced increase in plasma oxytocin was associated with a selective decrease in immediate free recall of unpleasant words from primacy positions. The present results add to evidence that cortisol-induced increases in oxytocin could mediate some of the effects of stress and cortisol on memory, and possibly play a role in the regulation of the hypothalamo-pituitary–adrenal stress response. This mechanism could significantly impact affective and social behaviors, in particular during times of stress. |
Keywords: | oxytocin cortisol adrenocorticotropic hormone memory stress hypothalamo-pituitary–adrenal axis vasopressin |
Rights: | © 2012 Tops, Buisman-Pijlman, Boksem, Wijers and Korf. This is an open-access article distributed under the terms of the Creative Commons Attribution Non Commercial License, which permits non-commercial use, distribution, and reproduction in other forums, provided the original authors and source are credited. |
DOI: | 10.3389/fpsyt.2012.00043 |
Published version: | http://dx.doi.org/10.3389/fpsyt.2012.00043 |
Appears in Collections: | Aurora harvest Pharmacology publications |
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