Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/73899
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Type: | Journal article |
Title: | Antenatal magnesium individual participant data international collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE) |
Author: | Crowther, C. Middleton, P. Askie, L. Doyle, L. Bubner, T. Voysey, M. |
Citation: | Systematic Reviews, 2012; 1(1):1-10 |
Publisher: | BioMed Central Ltd |
Issue Date: | 2012 |
ISSN: | 2046-4053 2046-4053 |
Statement of Responsibility: | C.A. Crowther, P.F. Middleton, L.M. Askie, L.W. Doyle, T.K. Bubner and M. Voysey |
Abstract: | BACKGROUND: The primary aim of this study is to assess, using individual participant data (IPD) meta-analysis, the effects of administration of antenatal magnesium sulphate given to women at risk of preterm birth on important clinical outcomes for their child such as death and neurosensory disability. The secondary aim is to determine whether treatment effects differ depending on important pre-specified participant and treatment characteristics, such as reasons at risk of preterm birth, gestational age, or type, dose and mode of administration of magnesium sulphate. METHODS: Design: The Antenatal Magnesium Individual Participant Data (IPD) International Collaboration: assessing the benefits for babies using the best level of evidence (AMICABLE) Group will perform an IPD meta-analysis to answer these important clinical questions. Setting/Timeline: The AMICABLE Group was formed in 2009 with data collection commencing late 2010. Inclusion Criteria: Five trials involving a total 6,145 babies are eligible for inclusion in the IPD meta-analysis. Primary study outcomes: For the infants/children: Death or cerebral palsy. For the women: Any severe maternal outcome potentially related to treatment (death, respiratory arrest or cardiac arrest). DISUCSSION: Results are expected to be publicly available in 2012. |
Keywords: | Preterm birth Magnesium sulphate Individual patient data Cerebral palsy Meta-analysis |
Rights: | © 2012 The AMICABLE Group; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
DOI: | 10.1186/2046-4053-1-21 |
Published version: | http://dx.doi.org/10.1186/2046-4053-1-21 |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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hdl_73899.pdf | Published version | 256.29 kB | Adobe PDF | View/Open |
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