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https://hdl.handle.net/2440/7403
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Type: | Journal article |
Title: | The water-soluble components of the essential oil of Melaleuca alternifolia (tea tree oil) suppress the production of superoxide by human monocytes, but not neutrophils, activated in vitro |
Author: | Brand, C. Ferrante, A. Prager, R. Riley, T. Carson, C. Finlay-Jones, J. Hart, P. |
Citation: | Inflammation Research, 2001; 50(4):213-219 |
Publisher: | Birkhauser Verlag Ag |
Issue Date: | 2001 |
ISSN: | 1023-3830 1420-908X |
Statement of Responsibility: | Brand, C.; Ferrante, A.; Prager, R.H.; Riley, T.V.; Carson, C.F.; Finlay-Jones, J.J.; Hart, P.H. |
Abstract: | <h4>Objective</h4>To evaluate the regulatory properties of the essential oil of Melaleuca alternifolia (tea tree oil) on the production of oxygen derived reactive species by human peripheral blood leukocytes activated in vitro.<h4>Materials and methods</h4>The ability of tea tree oil to reduce superoxide production by neutrophils and monocytes stimulated with N-formyl-methionyl-leucyl-phenylalanine (fMLP), lipopolysaccharide (LPS) or phorbol 12-myristate 13-acetate (PMA) was examined.<h4>Results</h4>The water-soluble fraction of tea tree oil had no significant effect on agonist-stimulated superoxide production by neutrophils, but significantly and dose-dependently suppressed agonist-stimulated superoxide production by monocytes. This suppression was not due to cell death. Chemical analysis identified the water-soluble components to be terpinen-4-ol, alpha-terpineol and 1,8-cineole. When examined individually, terpinen-4-ol significantly suppressed fMLP- and LPS- but not PMA-stimulated superoxide production; alpha-terpineol significantly suppressed fMLP-, LPS- and PMA-stimulated superoxide production; 1,8-cineole was without effect.<h4>Conclusion</h4>Tea tree oil components suppress the production of superoxide by monocytes, but not neutrophils, suggesting the potential for selective regulation of cell types by these components during inflammation. |
Keywords: | Neutrophils Monocytes Cells, Cultured Humans Superoxides Water Cyclohexanols Menthol Terpenes Tetradecanoylphorbol Acetate Monoterpenes Lipopolysaccharides Tea Tree Oil N-Formylmethionine Leucyl-Phenylalanine Anti-Infective Agents, Local Solubility Cyclohexenes Eucalyptol Cyclohexane Monoterpenes |
DOI: | 10.1007/s000110050746 |
Published version: | http://dx.doi.org/10.1007/s000110050746 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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