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https://hdl.handle.net/2440/74514
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Type: | Journal article |
Title: | Measurement of cardiac output during exercise in healthy, trained humans using lithium dilution and pulse contour analysis |
Author: | Elliott, A. Skowno, J. Prabhu, M. Ansley, L. |
Citation: | Physiological Measurement, 2012; 33(10):1691-1701 |
Publisher: | IOP Publishing Ltd |
Issue Date: | 2012 |
ISSN: | 0967-3334 1361-6579 |
Statement of Responsibility: | Adrian D Elliott, Justin Skowno, Mahesh Prabhu and Les Ansley |
Abstract: | The aim of this study was to evaluate the use of pulse contour analysis calibrated with lithium dilution in a single device (LiDCO™) for measurement of cardiac output (Q-dot) during exercise in healthy volunteers. We sought to; (a) compare pulse contour analysis (PulseCO) and lithium indicator dilution (LiDCO) for the measurement of Q-dot during exercise, and (b) assess the requirement for recalibration of PulseCO with LiDCO during exercise. Ten trained males performed multi-stage cycling exercise at intensities below and above ventilatory threshold before constant load maximal exercise to exhaustion. Uncalibrated PulseCO Q-dot (Q-dot raw) was compared to that calibrated with lithium dilution at baseline (Q-dot baseline), during submaximal exercise below (Q-dot low) and above (Q-dot high) ventilatory threshold, and at each exercise stage individually (Q-dot exercise). There was a significant difference between Q-dot baseline and all other calibration methods during exercise, but not at rest. No significant differences were observed between other methods. Closest agreement with Q-dot exercise was observed for Q-dot high (bias ± limits of agreement: 4.8 ± 30.0%). The difference between Q-dot exercise and both Q-dot low and Q-dot raw was characterized by low bias (4–7%) and wide limits of agreement (>±40%). Calibration of pulse contour analysis with lithium dilution prior to exercise leads to a systematic overestimation of exercising cardiac output. A single calibration performed during exercise above the ventilatory threshold provided acceptable limits of agreement with an approach incorporating multiple calibrations throughout exercise. Pulse contour analysis may be used for Q-dot measurement during exercise providing the system is calibrated during exercise. |
Keywords: | indicator dilution stroke volume haemodynamics arterial pressure waveform |
Rights: | © 2012 Institute of Physics and Engineering in Medicine |
DOI: | 10.1088/0967-3334/33/10/1691 |
Published version: | http://dx.doi.org/10.1088/0967-3334/33/10/1691 |
Appears in Collections: | Aurora harvest 4 Physiology publications |
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