Adelaide Research & Scholarship
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https://hdl.handle.net/2440/74648
| Type: | Patent |
| Title: | Altered Insulin-Like Growth Factor binding Proteins |
| Author: | Forbes, B. |
| Issue Date: | 2010 |
| Assignee: | University of Adelaide |
| Contributor: | A.P.T. Patent and Trade Mark Attorneys |
| Statement of Responsibility: | Invented by B. Forbes; assigened to University of Adelaide; A.P.T. Patent and Trade Mark Attorneys agent for inventors. |
| Abstract: | Altered IGFBPs are able to bind IGF but the release is inhibited by resistance to protease cleavage and/or reduced binding to extracellular matrix (ECM). Alterations have been made in IGFBP-2 to the linker domain in particular and two amino acid motifs found to be important for ECM binding. IGF-1 mediated proliferation of cancer cells have been inhibited by the use of these altered IGFBPs. |
| Keywords: | WO 2004/007543 A1 |
| Description: | PATENT: B. Forbes (Assignee: University of Adelaide). WO 2004/007543 A1 (PCT/AU2003/000898) filed Jul 11, 2003; published Jan 22, 2004 |
| Patent #: | 4559222 |
| Description (link): | http://www.patentlens.net/patentlens/patent/WO_2004_007543_A1/en/ |
| Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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