Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/74670
Type: | Patent |
Title: | Cytotoxin with a subtilase domain |
Author: | Paton, A. Paton, J. |
Issue Date: | 2006 |
Contributor: | Coleman, Henry D. Sudol, R. Neil Sapone, William J. |
Statement of Responsibility: | Inventors A. W. Paton, J. C. Paton; Assigned to Adelaide Research and Innovation Pty Ltd; R. N. Sudol, H. D. Coleman and W. J. Sapone agents to inventors. |
Abstract: | A member of a new class of bacterial toxin has been isolated and characterised. The bacterial toxin is of the AB₅ type and is characterised in that it has a subtilase domain. It is cytotoxic to Vero cells, and toxicity in vivo in mice occurs in a number of different sites. Mutation of the serine active residue results in greater than 99% reduction in activity. The protein has been purified and antibodies have been prepared for both the A subunit and B subunits, and ELISA detection methods have been developed. The nucleic acid sequence has been determined and primers specific for the toxin have been used for a preliminary screen of a range of patient samples to ascertain the extent to which the toxin is present. |
Keywords: | US 7078489 |
Description: | PATENT: A. W. Paton, J. C. Paton (Assignee Adelaide Research and Innovation Pty Ltd). US 7078489 filed May 12, 2004; published Jul 18, 2006; granted until May 12, 2024. |
Patent #: | 7078489 |
Description (link): | http://www.patentlens.net/patentlens/patent/US_7078489/en/ |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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