Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/74717
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Full metadata record
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dc.contributor.author | Gorman, S. | - |
dc.contributor.author | Scott, N. | - |
dc.contributor.author | Tan, D. | - |
dc.contributor.author | Weeden, C. | - |
dc.contributor.author | Tuckey, R. | - |
dc.contributor.author | Bisley, J. | - |
dc.contributor.author | Grimbaldeston, M. | - |
dc.contributor.author | Hart, P. | - |
dc.contributor.editor | Makishima, M. | - |
dc.date.issued | 2012 | - |
dc.identifier.citation | PLoS One, 2012; 7(9):1-12 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2440/74717 | - |
dc.description | Extent: 12p. | - |
dc.description.abstract | Vitamin D is synthesised by ultraviolet (UV) irradiation of skin and is hypothesized to be a direct mediator of the immunosuppression that occurs following UV radiation (UVR) exposure. Both UVR and vitamin D drive immune responses towards tolerance by ultimately increasing the suppressive activities of regulatory T cells. To examine a role for UVR-induced vitamin D, vitamin D₃-deficient mice were established by dietary vitamin D₃ restriction. In comparison to vitamin D₃-replete mice, vitamin D₃-deficient mice had significantly reduced serum levels of 25-hydroxyvitamin D₃ (25(OH)D₃, <20 nmol.L⁻¹) and 1,25-dihydroxyvitamin D₃ (1,25(OH)₂D₃, <20 pmol.L⁻¹). Following either acute erythemal UVR, or chronic sub-erythemal UVR (8 exposures over 4 weeks) treatment, serum 25(OH)D₃ levels significantly increased in vitamin D₃-deficient female but not male mice. To determine if UVR-induced vitamin D was a mediator of UVR-induced systemic immunosuppression, responses were measured in mice that were able (female) or unable (male) to increase systemic levels of 25(OH)D₃ after UVR. Erythemal UVR (≥4 kJ/m²) suppressed contact hypersensitivity responses (T helper type-1 or -17), aspects of allergic airway disease (T helper type-2) and also the in vivo priming capacity of bone marrow-derived dendritic cells to a similar degree in female and male vitamin D₃-deficient mice. Thus, in male mice, UVR-induced 25(OH)D₃ is not essential for mediating the immunosuppressive effects of erythemal UVR. | - |
dc.description.statementofresponsibility | Shelley Gorman, Naomi M. Scott, Daryl H. W. Tan, Clare E. Weeden, Robert C. Tuckey, Jacqueline L. Bisley, Michele A. Grimbaldeston, Prue H. Hart | - |
dc.language.iso | en | - |
dc.publisher | Public Library of Science | - |
dc.rights | © 2012 Gorman et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | - |
dc.source.uri | http://dx.doi.org/10.1371/journal.pone.0046006 | - |
dc.subject | Dendritic Cells | - |
dc.subject | Bone Marrow Cells | - |
dc.subject | Skin | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred BALB C | - |
dc.subject | Mice | - |
dc.subject | Erythema | - |
dc.subject | Acute Disease | - |
dc.subject | Calcium | - |
dc.subject | Calcifediol | - |
dc.subject | Vitamin D | - |
dc.subject | Immunosuppressive Agents | - |
dc.subject | Bronchoalveolar Lavage | - |
dc.subject | Ultraviolet Rays | - |
dc.subject | Dose-Response Relationship, Radiation | - |
dc.subject | Immune Tolerance | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Immunosuppression Therapy | - |
dc.title | Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D-₃ levels in male mice | - |
dc.title.alternative | Acute erythemal ultraviolet radiation causes systemic immunosuppression in the absence of increased 25-hydroxyvitamin D-(3) levels in male mice | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1371/journal.pone.0046006 | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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hdl_74717.pdf | Published version | 1.81 MB | Adobe PDF | View/Open |
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