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https://hdl.handle.net/2440/7477
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Type: | Journal article |
Title: | Longitudinal follow-up of the intellectual and academic functioning of children receiving central nervous system-prophylactic chemotherapy for leukemia: A four-year final report |
Author: | Brown, R. Sawyer, M. Antoniou, G. Toogood, I. Rice, M. |
Citation: | Journal of Developmental and Behavioral Pediatrics, 1999; 20(5):373-377 |
Publisher: | Lippincott, Williams & Wilkins |
Issue Date: | 1999 |
ISSN: | 0196-206X 1536-7312 |
Statement of Responsibility: | Ronald T. Brown, Michael G. Sawyer, Georgia Antoniou, Ian Toogood, Michael Rice |
Abstract: | This longitudinal investigation extends our prospective study of the intellectual and academic functioning of children treated for cancer to 4 years after diagnosis. In the longer term, the children who received central nervous system (CNS) chemotherapy experienced greater neurocognitive deficits, particularly in the area of academic achievement, than did the children who did not receive CNS chemotherapy. Specifically, the CNS chemotherapy-treated children scored lower on academic tests of reading at 3 and 4 years after diagnosis. The results suggest that CNS chemotherapy prophylaxis may adversely effect the development of higher-order mental abilities and cognitive skills during the late-effects period and may also impair academic achievement. |
Keywords: | Humans Leukemia Central Nervous System Neoplasms Neoplasm Recurrence, Local Antineoplastic Agents Severity of Illness Index Follow-Up Studies Prospective Studies Achievement Cognition Disorders Adolescent Child Male |
Rights: | © 1999 by Lippincott, Williams & Wilkins, Inc |
DOI: | 10.1097/00004703-199910000-00013 |
Published version: | http://dx.doi.org/10.1097/00004703-199910000-00013 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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