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https://hdl.handle.net/2440/75040
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Type: | Journal article |
Title: | Lysosomal secretion of Flightless I upon injury has the potential to alter inflammation |
Author: | Cowin, A. Lei, N. Franken, L. Ruzehaji, N. Offenhauser, C. Kopecki, Z. Murray, R. |
Citation: | Communicative and Integrative Biology, 2012; 5(6):546-549 |
Publisher: | Landes Bioscience |
Issue Date: | 2012 |
ISSN: | 1942-0889 1942-0889 |
Statement of Responsibility: | Allison J. Cowin, Nazi Lei, Linda Franken, Nadira Ruzehaji, Carolin Offenhäuser, Zlatko Kopecki and Rachael Z. Murray |
Abstract: | Intracellular Flightless I (Flii), a gelsolin family member, has been found to have roles modulating actin regulation, transcriptional regulation and inflammation. In vivo Flii can regulate wound healing responses. We have recently shown that a pool of Flii is secreted by fibroblasts and macrophages, cells typically found in wounds, and its secretion can be upregulated upon wounding. We show that secreted Flii can bind to the bacterial cell wall component lipopolysaccharide and has the potential to regulate inflammation. We now show that secreted Flii is present in both acute and chronic wound fluid. |
Keywords: | Cathepsin D, Flightless I, Rab 7 and Stx11, late endosome, lysosome, secretion |
Rights: | © 2012 Landes Bioscience |
DOI: | 10.4161/cib.21928 |
Published version: | http://dx.doi.org/10.4161/cib.21928 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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