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https://hdl.handle.net/2440/75461
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dc.contributor.author | Gregori, S. | - |
dc.contributor.author | Tomasoni, D. | - |
dc.contributor.author | Pacciani, V. | - |
dc.contributor.author | Scirpoli, M. | - |
dc.contributor.author | Battaglia, M. | - |
dc.contributor.author | Magnani, C. | - |
dc.contributor.author | Hauben, E. | - |
dc.contributor.author | Roncarolo, M. | - |
dc.date.issued | 2010 | - |
dc.identifier.citation | Blood, 2010; 116(6):935-944 | - |
dc.identifier.issn | 0006-4971 | - |
dc.identifier.issn | 1528-0020 | - |
dc.identifier.uri | http://hdl.handle.net/2440/75461 | - |
dc.description.abstract | Type 1 T regulatory (Tr1) cells suppress immune responses in vivo and in vitro and play a key role in maintaining tolerance to self- and non–self-antigens. Interleukin-10 (IL-10) is the crucial driving factor for Tr1 cell differentiation, but the molecular mechanisms underlying this induction remain unknown. We identified and characterized a subset of IL-10–producing human dendritic cells (DCs), termed DC-10, which are present in vivo and can be induced in vitro in the presence of IL-10. DC-10 are CD14+, CD16+, CD11c+, CD11b+, HLA-DR+, CD83+, CD1a−, CD1c−, express the Ig-like transcripts (ILTs) ILT2, ILT3, ILT4, and HLA-G antigen, display high levels of CD40 and CD86, and up-regulate CD80 after differentiation in vitro. DC-10 isolated from peripheral blood or generated in vitro are potent inducers of antigen-specific IL-10–producing Tr1 cells. Induction of Tr1 cells by DC-10 is IL-10–dependent and requires the ILT4/HLA-G signaling pathway. Our data indicate that DC-10 represents a novel subset of tolerogenic DCs, which secrete high levels of IL-10, express ILT4 and HLA-G, and have the specific function to induce Tr1 cells. | - |
dc.description.statementofresponsibility | Silvia Gregori, Daniela Tomasoni, Valentina Pacciani, Miriam Scirpoli, Manuela Battaglia, Chiara Francesca Magnani, Ehud Hauben, and Maria-Grazia Roncarolo | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Hematology | - |
dc.rights | © 2010 by The American Society of Hematology | - |
dc.source.uri | http://dx.doi.org/10.1182/blood-2009-07-234872 | - |
dc.subject | Dendritic Cells | - |
dc.subject | Monocytes | - |
dc.subject | Humans | - |
dc.subject | Membrane Glycoproteins | - |
dc.subject | Receptors, Immunologic | - |
dc.subject | Interleukin-10 | - |
dc.subject | Interleukin-12 | - |
dc.subject | Histocompatibility Antigens Class I | - |
dc.subject | HLA Antigens | - |
dc.subject | Flow Cytometry | - |
dc.subject | Immunophenotyping | - |
dc.subject | Cell Communication | - |
dc.subject | Signal Transduction | - |
dc.subject | Cell Differentiation | - |
dc.subject | Immune Tolerance | - |
dc.subject | Gene Expression | - |
dc.subject | T-Lymphocytes, Regulatory | - |
dc.subject | HLA-G Antigens | - |
dc.title | Differentiation of type 1 T regulatory (Tr1) cells by tolerogenic DC-10 requires the IL-10-dependent ILT4/HLA-G pathway | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1182/blood-2009-07-234872 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Hauben, E. [0000-0002-6062-411X] | - |
Appears in Collections: | Aurora harvest 4 Surgery publications |
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