Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7618
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Cisapride in the control of symptoms in infants with gastroesophageal reflux: A randomized, double-blind, placebo-controlled trial |
Author: | Cohen, R. O'Loughlin, E. Davidson, G. Moore, D. Lawrence, D. |
Citation: | Journal of Pediatrics, 1999; 134(3):287-292 |
Publisher: | MOSBY-ELSEVIER |
Issue Date: | 1999 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Cohen, Ralph C. ; O’Loughlin, Edward V. ; Davidson, Geoffrey P. ; Moore, D.J. ; Lawrence, Diana M. |
Abstract: | <h4>Objective</h4>To evaluate the efficacy of cisapride in the treatment of uncomplicated gastroesophageal reflux in children younger than 36 months of age.<h4>Study design</h4>A total of 95 patients satisfied the entry criteria and were randomly assigned to double-blind treatment with either cisapride (n = 50), 0.2 mg/kg 4 times daily, or placebo (n = 45) for 2 weeks. At the end of the 2-week treatment period, symptom diary and parental evaluation with repeat 24-hour pH study were performed.<h4>Results</h4>Sixty-eight patients completed the trial (38 in the cisapride group and 30 in the placebo group). There were no significant differences in the symptoms of crying, vomiting, or gagging; the overall symptom intensity score; or parental global evaluations. There was a significant difference (P <.03) in the percent time pH <4, the number of reflux episodes lasting more than 5 minutes, and the duration of the longest episode. No significant difference was demonstrated for the number of episodes with pH <4 or the reflux score.<h4>Conclusions</h4>Cisapride was no better than placebo for relief of symptoms in children with uncomplicated gastroesophageal reflux. A beneficial effect was demonstrated in the cisapride group in relation to the measured parameters for esophageal acid exposure time. |
Keywords: | Esophagus Humans Gastroesophageal Reflux Cisapride Gastrointestinal Agents Placebos Treatment Failure Administration, Oral Chi-Square Distribution Statistics, Nonparametric Double-Blind Method Hydrogen-Ion Concentration Infant Australia Female Male |
DOI: | 10.1016/S0022-3476(99)70451-8 |
Published version: | http://dx.doi.org/10.1016/s0022-3476(99)70451-8 |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.