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https://hdl.handle.net/2440/7623
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Type: | Journal article |
Title: | Folic acid improves endothelial function in children and adolescents with type 1 diabetes |
Author: | Pena Vargas, A. Wiltshire, E. Gent, R. Hirte, C. Couper, J. |
Citation: | Journal of Pediatrics, 2004; 144(4):500-504 |
Publisher: | Mosby Inc |
Issue Date: | 2004 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Alexia Sophie Peña, Esko Wiltshire, Roger Gent, Craig Hirte and Jennifer Couper |
Abstract: | Objective: To evaluate the effect of folate supplementation on endothelial function in children and adolescents with type 1 diabetes. Study design: Thirty-six subjects with type 1 diabetes age 13.6±2.6 years completed a randomized, double-blind, placebo-controlled crossover trial. Each subject received 8 weeks of oral folic acid (5 mg/d) and 8 weeks of placebo, with an 8-week washout period. Before and after each intervention, we assessed endothelial function by using brachial artery responses to flow (flow-mediated dilatation [FMD]) and glyceryl trinitrate, von Willebrand factor, glucose, hemoglobin A1c, total plasma homocyst(e)ine (tHcy), vitamin B12, serum folate, and red cell folate (RCF). Results: Folic acid increased FMD by 2.58 (3.1-5.7) % (95% confidence interval, 1.28-3.88), whereas placebo did not change FMD (–0.42%; 95% confidence interval, –1.67 to 0.83; P<.001). Folic acid increased serum folate by 14 nmol/L (6.2 ng/mL, P<.001) and RCF by 467.2 nmol/L (206 ng/mL, P<.001). Change in FMD was related to change in serum folate (r=0.46, P=.005) and RCF (r=0.39, P=.02). Glyceryl trinitrate responses, von Willebrand factor, tHcy, and hemoglobin A1c were not affected by the intervention. Conclusions: Short-term high-dose folic acid improves endothelial function in children and adolescents with type 1 diabetes and normal folate status independently of tHcy. |
Keywords: | Brachial Artery Endothelium, Vascular Erythrocytes Humans Diabetes Mellitus, Type 1 Folic Acid Hematinics Ultrasonography Blood Flow Velocity Treatment Outcome Administration, Oral Cross-Over Studies Double-Blind Method Adolescent Female Male |
DOI: | 10.1016/j.jpeds.2003.12.049 |
Description (link): | http://www.elsevier.com/wps/find/journaldescription.cws_home/623311/description#description |
Published version: | http://dx.doi.org/10.1016/j.jpeds.2003.12.049 |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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