Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7626
Citations | ||
Scopus | Web of ScienceĀ® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Mechanisms of gastroesophageal reflux in healthy premature infants |
Author: | Omari, T. Barnett, C. Snel, A. Goldsworthy, W. Haslam, R. Davidson, G. Kirubakaron, C. Bakewell, M. Fraser, R. Dent, J. |
Citation: | Journal of Pediatrics, 1998; 133(5):650-654 |
Publisher: | MOSBY-ELSEVIER |
Issue Date: | 1998 |
ISSN: | 0022-3476 1097-6833 |
Statement of Responsibility: | Taher I. Omari, Christopher Barnett, Antonie Snel, Wendy Goldsworthy, Ross Haslam, Geoff Davidson, Chellam Kirubakaran, Malcolm Bakewell, Robert Fraser and John Dent |
Abstract: | <h4>Objectives</h4>The aim of this study was to characterize the motor events responsible for gastroesophageal reflux (GER) and esophageal acid clearance in a cohort of healthy preterm infants.<h4>Study design</h4>Esophageal motility was recorded for 2 to 3 hours after a feeding in 24 preterm infants, 31 to 38 weeks' postmenstrual age, by using a sleeveside hole micromanometric assembly incorporating a pH probe.<h4>Results</h4>Sixty acid GER episodes were recorded by pH probe, and 133 non-acid GER episodes were recorded manometrically by the presence of esophageal common cavities. Of the 193 GER episodes, 159 (82%) were associated with transient lower esophageal sphincter relaxation (TLESR). TLESRs were significantly longer in duration than single swallows (15.1 seconds vs 5.6 seconds, P < .001) and had lower nadir pressures (0.8 mm Hg vs 2.3 mm Hg, P < .001). A total of 3216 esophageal body pressure waves were analyzed; 70% of swallow-induced pressure waves were peristaltic in sequence compared with 5% of swallow-unrelated pressure waves. During periods of esophageal acidification (pH below 4), peristaltic esophageal body pressure wave sequences cleared acid refluxate more effectively than nonperistaltic pressure wave sequences.<h4>Conclusions</h4>In healthy preterm infants, TLESRs are the predominant mechanism underlying GER, and esophageal clearance mechanisms are well developed by at least 31 weeks' postmenstrual age. |
Keywords: | Esophagus Esophagogastric Junction Gastric Acid Humans Gastroesophageal Reflux Infant, Premature, Diseases Gastric Acidity Determination Cohort Studies Manometry Peristalsis Infant, Newborn Female Male |
DOI: | 10.1016/S0022-3476(98)70106-4 |
Published version: | http://dx.doi.org/10.1016/s0022-3476(98)70106-4 |
Appears in Collections: | Aurora harvest Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.