Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/76391
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | The GM-CSF receptor family: mechanism of activation and implications for disease |
Author: | Hercus, T. Broughton, S. Ekert, P. Ramshaw, H. Perugini, M. Grimbaldeston, M. Woodcock, J. Thomas, D. Pitson, S. Hughes, T. D'Andrea, R. Parker, M. Lopez, A. |
Citation: | Growth Factors, 2012; 30(2):63-75 |
Publisher: | Taylor & Francis Ltd |
Issue Date: | 2012 |
ISSN: | 0897-7194 1029-2292 |
Statement of Responsibility: | Timothy R. Hercus, Sophie E. Broughton, Paul G. Ekert,Hayley S. Ramshaw, Michelle Perugini, Michele Grimbaldeston, Joanna M. Woodcock, Daniel Thomas, Stuart Pitson, Timothy Hughes, Richard J. D’andrea, Michael W. Parker, & Angel F. Lopez |
Abstract: | Granulocyte-macrophage colony-stimulating factor (GM-CSF) is a pluripotent cytokine produced by many cells in the body, which regulates normal and malignant hemopoiesis as well as innate and adaptive immunity. GM-CSF assembles and activates its heterodimeric receptor complex on the surface of myeloid cells, initiating multiple signaling pathways that control key functions such as cell survival, cell proliferation, and functional activation. Understanding the molecular composition of these pathways, the interaction of the various components as well as the kinetics and dose-dependent mechanics of receptor activation provides valuable insights into the function of GM-CSF as well as the related cytokines, interleukin-3 and interleukin-5. This knowledge provides opportunities for the development of new therapies to block the action of these cytokines in hematological malignancy and chronic inflammation. |
Keywords: | Activation cytokine GM-CSF signaling receptor |
Rights: | © 2012 Informa UK, Ltd. |
DOI: | 10.3109/08977194.2011.649919 |
Grant ID: | http://purl.org/au-research/grants/nhmrc/565217 http://purl.org/au-research/grants/arc/FF0669018 |
Published version: | http://dx.doi.org/10.3109/08977194.2011.649919 |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.