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https://hdl.handle.net/2440/76406
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Type: | Journal article |
Title: | Elevated serum cytokine levels using cytometric bead arrays predict culture-positive infections in childhood oncology patients with febrile neutropenia |
Author: | Badurdeen, S. Hodge, G. Osborn, M. Scott, J. St John-Green, C. Tapp, H. Zola, H. Revesz, T. |
Citation: | Journal of Pediatric Hematology/Oncology, 2012; 34(1):E36-E38 |
Publisher: | Lippincott Williams & Wilkins |
Issue Date: | 2012 |
ISSN: | 1077-4114 1536-3678 |
Statement of Responsibility: | Badurdeen, Shiraz; Hodge, Greg; Osborn, Michael; Scott, Julius; St. John-Green, Celia; Tapp, Heather; Zola, Heddy; Revesz, Tamas |
Abstract: | Neutropenic patients with bacteraemia need prolonged intravenous antibiotic treatment. Using cytometric bead array technology, we show in children with febrile neutropenia that bacteraemia is associated with an elevation of at least 1 of 3 plasma cytokines plus C-reactive protein. The combination of interleukin (IL)-8, IL-6, IL-10, and C-reactive protein values above operator-defined cutoff levels identified 15 of 16 episodes of bacteraemia, making this a potentially useful technique in identifying high-risk patients who should not be discharged early from hospital. Furthermore, low risk of bacteraemia may be predicted by a combination of below threshold cytokines and negative clinical examination. |
Keywords: | febrile neutropenia cytokine prediction bacteraemia |
Rights: | © 2012 Lippincott Williams & Wilkins, Inc. |
DOI: | 10.1097/MPH.0b013e3182193009 |
Published version: | http://dx.doi.org/10.1097/mph.0b013e3182193009 |
Appears in Collections: | Aurora harvest Paediatrics publications |
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