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https://hdl.handle.net/2440/76710
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dc.contributor.author | Gaysina, D. | - |
dc.contributor.author | Cohen-Woods, S. | - |
dc.contributor.author | Chow, P. | - |
dc.contributor.author | Martucci, L. | - |
dc.contributor.author | Schosser, A. | - |
dc.contributor.author | Ball, H. | - |
dc.contributor.author | Tozzi, F. | - |
dc.contributor.author | Perry, J. | - |
dc.contributor.author | Muglia, P. | - |
dc.contributor.author | Craig, I. | - |
dc.contributor.author | McGuffin, P. | - |
dc.contributor.author | Farmer, A. | - |
dc.date.issued | 2009 | - |
dc.identifier.citation | American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 2009; 150B(6):836-844 | - |
dc.identifier.issn | 1552-4841 | - |
dc.identifier.issn | 1552-485X | - |
dc.identifier.uri | http://hdl.handle.net/2440/76710 | - |
dc.description.abstract | Recent studies suggest a degree of overlap in genetic susceptibility across the traditional categories of schizophrenia and bipolar disorder. There is some evidence for an association of the dystrobrevin binding protein 1 gene (DTNBP1) with schizophrenia, and, thus, this gene has also become a focus of further investigation in bipolar disorder (BD). The aim of our study is to explore the association of DTNBP1 with BD and with a sub phenotype, presence/absence of psychotic symptoms, in a sample of 515 patients with BD (ICD10/DSMIV) and 1,316 ethnically matched control subjects recruited from the UK. Seven DTNBP1 SNPs: rs2743852 (SNP C), rs760761 (P1320), rs1011313 (P1325), rs3213207 (P1635), rs2619539 (P1655), rs16876571 and rs17470454 were investigated using the SNPlex genotyping system and 1 SNP (rs2619522) genotypes were imputed. Association analyses were conducted in a sample of 452 cases and 956 controls. We found significant differences in genotypic and allelic frequencies of rs3213207 and rs760761 of DTNBP1 between bipolar patients and controls. We also showed a global haplotypic association and an association of a particular haplotype with BD. Our results are consistent with previous studies in term of a general association between DTNBP1 and bipolar disorder and provide additional evidence that a portion of the genotypic overlap between schizophrenia and bipolar affective disorder is attributable to this gene. | - |
dc.description.statementofresponsibility | Darya Gaysina, Sarah Cohen-Woods, Philip C. Chow, Livia Martucci, Alexandra Schosser, Harriet A. Ball, Federica Tozzi, Julia Perry, Pierandrea Muglia, Ian W. Craig, Peter McGuffin, and Anne Farmer | - |
dc.language.iso | en | - |
dc.publisher | Wiley-Liss | - |
dc.rights | Copyright © 2008 Wiley-Liss, Inc. | - |
dc.source.uri | http://dx.doi.org/10.1002/ajmg.b.30906 | - |
dc.subject | dysbindin | - |
dc.subject | affective disorder | - |
dc.subject | association | - |
dc.subject | psychosis | - |
dc.subject | haplotype | - |
dc.title | Association of the dystrobrevin binding protein 1 gene (DTNBP1) in a bipolar case-control study (BACCS) | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1002/ajmg.b.30906 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Cohen-Woods, S. [0000-0003-2199-6129] | - |
Appears in Collections: | Aurora harvest 4 Psychiatry publications |
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