Adelaide Research & Scholarship
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https://hdl.handle.net/2440/76722
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| Type: | Journal article |
| Title: | Tailoring an alien ferredoxin to support native-like P450 monooxygenase activity |
| Author: | Bell, S. McMillan, J. Yorke, J. Kavanagh, E. Johnson, E. Wong, L. |
| Citation: | Chemical Communications, 2012; 48(95):11692-11694 |
| Publisher: | Royal Soc Chemistry |
| Issue Date: | 2012 |
| ISSN: | 1359-7345 1364-548X |
| Statement of Responsibility: | Stephen G. Bell, James H. C. McMillan, Jake A. Yorke, Emma Kavanagh, Eachan O. D. Johnson, and Luet-Lok Wong |
| Abstract: | A ferredoxin associated with biological Fe-S cluster assembly has been remodelled to transfer electrons to a P450 enzyme and support substrate oxidation at 80% of the physiological ferredoxin activity, opening up the possibility of tailoring ferredoxins to reconstitute the activity of P450 enzymes for which the electron transfer partner proteins are not known. |
| Keywords: | Sulfur Iron Cytochrome P-450 Enzyme System Ferredoxins Recombinant Proteins Protein Structure, Tertiary Protein Binding Electron Transport Oxidation-Reduction Kinetics Mutation |
| Rights: | © Royal Society of Chemistry 2012 |
| DOI: | 10.1039/c2cc35968e |
| Published version: | http://dx.doi.org/10.1039/c2cc35968e |
| Appears in Collections: | Aurora harvest 4 Chemistry publications |
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