Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/76994
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dc.contributor.authorAl-Azri, A.-
dc.contributor.authorGibson, R.-
dc.contributor.authorKeefe, D.-
dc.contributor.authorLogan, R.-
dc.date.issued2013-
dc.identifier.citationOral Diseases, 2013; 19(4):347-359-
dc.identifier.issn1354-523X-
dc.identifier.issn1601-0825-
dc.identifier.urihttp://hdl.handle.net/2440/76994-
dc.description.abstractMatrix metalloproteinases (MMPs) are critical factors in maintaining the integrity of mucosa and mediating normal biological processes. An imbalance between tissue levels of these mediators and their natural inhibitors is believed to underlie the pathophysiology of many diseases, including those affect the gastrointestinal and oral mucosae. The ongoing development of synthetic inhibitors of these mediators may provide opportunities to develop treatment modalities for patients suffering from these diseases. Understanding the role of MMPs in the pathophysiology of many diseases, however, is far from complete, and the improvement of pharmaceutical management strategies can only be achieved if the underlying process of these diseases is completely comprehended. This paper reviews the functions of matrix metalloproteinases and addresses their role in mediating mucosal pathologies with emphasis on oral mucosa.-
dc.description.statementofresponsibilityA.R. Al-Azri, R.J. Gibson, D.M.K. Keefe and R.M. Logan-
dc.language.isoen-
dc.publisherBlackwell Munksgaard-
dc.rights© 2012 John Wiley & Sons A/S-
dc.source.urihttp://dx.doi.org/10.1111/odi.12023-
dc.subjectMatrix metalloproteinases-
dc.subjecttissue inhibitors of metalloproteinases-
dc.subjectoral disease-
dc.subjectextracellular matrix-
dc.titleMatrix metalloproteinases: do they play a role in mucosal pahology of the oral cavity?-
dc.typeJournal article-
dc.identifier.doi10.1111/odi.12023-
pubs.publication-statusPublished-
dc.identifier.orcidAl-Azri, A. [0000-0002-2618-9679]-
dc.identifier.orcidGibson, R. [0000-0002-4796-1621]-
dc.identifier.orcidKeefe, D. [0000-0001-9377-431X]-
dc.identifier.orcidLogan, R. [0000-0002-9331-1814]-
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