Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/7761
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Gibson, L. | - |
dc.contributor.author | Holmgreen, S. | - |
dc.contributor.author | Huang, D. | - |
dc.contributor.author | Bernand, O. | - |
dc.contributor.author | Copeland, N. | - |
dc.contributor.author | Jenkins, N. | - |
dc.contributor.author | Sutherland, G. | - |
dc.contributor.author | Baker, E. | - |
dc.contributor.author | Adams, J. | - |
dc.contributor.author | Cory, S. | - |
dc.date.issued | 1996 | - |
dc.identifier.citation | Oncogene, 1996; 13(4):665-675 | - |
dc.identifier.issn | 0950-9232 | - |
dc.identifier.issn | 1476-5594 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7761 | - |
dc.description.abstract | The prototypic mammalian regulator of cell death is bcl-2, the oncogene implicated in the development of human follicular lymphoma. Several homologues of bcl-2 are now known. Using a PCR-based strategy we cloned a novel member of this gene family, denoted bcl-w. The gene, which is highly conserved between mouse and human, resides near the T-cell antigen receptor alpha gene within the central portion of mouse chromosome 14 and on human chromosome 14 at band q11. Enforced expression of bcl-w rendered lymphoid and myeloid cells refractory to several (but not all) cytotoxic conditions. Thus, like Bcl-2 and Bcl-x, the Bcl-w protein promotes cell survival, in contrast to other close homologues, Bax and Bak, which facilitate cell death. Comparison of the expected amino acid sequence of Bcl-w with that of these relatives helps to delineate residues likely to convey survival or anti-survival function. While expression of bcl-w was uncommon in B or T lymphoid cell lines, the mRNA was observed in almost all murine myeloid cell lines analysed and in a wide range of tissues. These findings suggest that bcl-w participates in the control of apoptosis in multiple cell types. Its functional similarity to bcl-2 also makes it an attractive candidate proto-oncogene. | - |
dc.description.statementofresponsibility | Gibson, L ; Holmgreen, S P ; Huang, D C ; Bernard, O ; Copeland, N G ; Jenkins, N A ; Sutherland, G R ; Baker, E ; Adams, J M ; Cory, S | - |
dc.language.iso | en | - |
dc.publisher | NATURE PUBLISHING GROUP | - |
dc.subject | Chromosomes, Human, Pair 14 | - |
dc.subject | Animals | - |
dc.subject | Mice, Inbred C57BL | - |
dc.subject | Humans | - |
dc.subject | Mice | - |
dc.subject | Proteins | - |
dc.subject | Proto-Oncogene Proteins | - |
dc.subject | Proto-Oncogene Proteins c-bcl-2 | - |
dc.subject | DNA, Complementary | - |
dc.subject | Chromosome Mapping | - |
dc.subject | Cloning, Molecular | - |
dc.subject | Cell Survival | - |
dc.subject | Amino Acid Sequence | - |
dc.subject | Base Sequence | - |
dc.subject | Sequence Homology, Amino Acid | - |
dc.subject | Multigene Family | - |
dc.subject | Molecular Sequence Data | - |
dc.subject | Female | - |
dc.subject | Male | - |
dc.subject | Apoptosis Regulatory Proteins | - |
dc.subject | Proto-Oncogene Mas | - |
dc.title | bcl-w, a novel member of the bcl-2 family, promotes cell survival | - |
dc.type | Journal article | - |
pubs.publication-status | Published | - |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.