Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/78123
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Vitamin D actions to regulate calcium and skeletal homeostasis |
Author: | Anderson, P. Turner, A. Morris, H. |
Citation: | Clinical Biochemistry, 2012; 45(12):880-886 |
Publisher: | Pergamon-Elsevier Science Ltd |
Issue Date: | 2012 |
ISSN: | 0009-9120 1873-2933 |
Statement of Responsibility: | Paul H. Anderson, Andrew G. Turner, Howard A. Morris |
Abstract: | The endocrine action of plasma 1,25-dihydroxyvitamin D plays a key role in the regulation of plasma calcium and phosphate homeostasis with activities on the intestine, kidney and bone. A current, controversial question is whether vitamin D exerts direct actions on bone cells to regulate bone mineral homeostasis. Results from clinical, rodent model and in vitro studies on human bone cells provide an impressive body of data to support this proposal particularly at the level of serum 25-hydroxyvitamin D status. Each of the major bone cell types is capable of metabolising vitamin D to the active metabolite, 1,25-dihydroxyvitamin D. Thus under conditions when bone tissue synthesis of 1,25-dihydroxyvitamin D is optimal, vitamin D activity enhances bone mineral status. Dietary calcium and phosphate intakes are the critical environmental cues together with vitamin D status to determine whether 1,25-dihydroxyvitamin D exerts an anabolic or catabolic action on bone mineral status. |
Keywords: | Vitamin D Vitamin D metabolism 25-hydroxyvitamin D critical serum levels Dietary calcium Metabolic bone disease Osteoporosis Osteomalacia/rickets Calcium homeostasis |
Rights: | Copyright © 2012 The Canadian Society of Clinical Chemists |
DOI: | 10.1016/j.clinbiochem.2012.02.020 |
Published version: | http://dx.doi.org/10.1016/j.clinbiochem.2012.02.020 |
Appears in Collections: | Aurora harvest Biochemistry publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.