Please use this identifier to cite or link to this item: https://hdl.handle.net/2440/78555
Citations
Scopus Web of Science® Altmetric
?
?
Full metadata record
DC FieldValueLanguage
dc.contributor.authorBurgstad, C.-
dc.contributor.authorBesanko, L.-
dc.contributor.authorDeane, A.-
dc.contributor.authorNguyen, Q.-
dc.contributor.authorSaadat-Gilani, K.-
dc.contributor.authorDavidson, G.-
dc.contributor.authorBurt, E.-
dc.contributor.authorThomas, A.-
dc.contributor.authorHolloway, R.-
dc.contributor.authorChapman, M.-
dc.contributor.authorFraser, R.-
dc.date.issued2013-
dc.identifier.citationCritical Care Medicine, 2013; 41(5):1221-1228-
dc.identifier.issn0090-3493-
dc.identifier.issn1530-0293-
dc.identifier.urihttp://hdl.handle.net/2440/78555-
dc.description.abstract<h4>Objective</h4>Inadequate nutrition is common in critical illness due in part to gastric stasis. However, recent data suggest that altered small intestinal mucosal function may be a contributing factor. The aim of this study was to examine the effects of critical illness on sucrose absorption, permeability, and mucosal morphology.<h4>Design</h4>Prospective, observational study.<h4>Setting</h4>Tertiary critical care unit.<h4>Subjects</h4>Twenty mechanically ventilated patients (19 men; 52.2 ± 20.5 yr; 9 feed intolerant; Acute Physiology and Chronic Health Evaluation II score 16.2 ± 6.0) and 20 healthy subjects (14 men; 51.6 ± 21.5 yr).<h4>Interventions</h4>Following a 4-hr fast, a "meal" (100 kcal Ensure, 20-g enriched C-sucrose, 1.1 g rhamnose, 7.5 mL lactulose) was administered into the small intestine. Sucrose absorption was evaluated by analyzing 13CO2 concentration (cumulative percent of administered 13C dose recovered) in expiratory breath samples taken at timed intervals. At 90 minutes, a plasma lactulose/rhamnose concentration was also measured, with lactulose/rhamnose ratio, a marker of small intestinal mucosal permeability. When possible duodenal biopsies were taken in critically ill patients on insertion of the small intestinal feeding catheter and examined for disaccharidase levels and histology. Data are mean ± SD.<h4>Results</h4>When compared with healthy subjects, critically ill patients had significantly reduced cumulative CO2 recovery (90 min: 1.78% ± 1.98% vs. 8.04% ± 2.55%; p < 0.001) and increased lactulose/rhamnose ratio (2.77 ± 4.24 vs.1.10 ± 0.98; p = 0.03). The lactulose/rhamnose ratio was greater in feed-intolerant patients (4.06 ± 5.38; p = 0.003). In five patients, duodenal mucosal biopsy showed mild to moderate epithelial injury. Sucrase levels were normal in all patients.<h4>Conclusions</h4>Sucrose absorption is reduced and intestinal permeability increased in critically ill patients, possibly indicating an impairment of small intestinal mucosal function. These results, however, are discordant with duodenal mucosal histology and sucrase levels. This may reflect an inactivation of sucrase in vivo or inadequate nutrient exposure to the brush border due to small intestinal dysmotility.-
dc.description.statementofresponsibilityCarly M. Burgstad, Laura K. Besanko, Adam M. Deane, Nam Q. Nguyen, Khaschayar Saadat-Gilani, Geoff Davidson, Esther Burt, Anthony Thomas, Richard H. Holloway, Marianne J. Chapman and Robert J.L. Fraser-
dc.language.isoen-
dc.publisherLippincott Williams & Wilkins-
dc.rightsCopyright: © 2013 by the Society of Critical Care Medicine and Lippincott Williams & Wilkins-
dc.source.urihttp://dx.doi.org/10.1097/ccm.0b013e31827ca2fa-
dc.subjectIntestinal Mucosa-
dc.subjectHumans-
dc.subjectMalabsorption Syndromes-
dc.subjectCritical Illness-
dc.subjectDietary Sucrose-
dc.subjectBreath Tests-
dc.subjectEnteral Nutrition-
dc.subjectRisk Assessment-
dc.subjectCase-Control Studies-
dc.subjectCohort Studies-
dc.subjectFollow-Up Studies-
dc.subjectProspective Studies-
dc.subjectIntestinal Absorption-
dc.subjectReference Values-
dc.subjectAdult-
dc.subjectAged-
dc.subjectMiddle Aged-
dc.subjectFemale-
dc.subjectMale-
dc.titleSucrose malabsorption and impaired mucosal integrity in enterally fed critically ill patients: a prospective cohort observational study-
dc.typeJournal article-
dc.identifier.doi10.1097/CCM.0b013e31827ca2fa-
pubs.publication-statusPublished-
dc.identifier.orcidDeane, A. [0000-0002-7620-5577]-
dc.identifier.orcidNguyen, Q. [0000-0002-1270-5441]-
dc.identifier.orcidChapman, M. [0000-0003-0710-3283]-
Appears in Collections:Aurora harvest 4
Medicine publications

Files in This Item:
There are no files associated with this item.


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.