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https://hdl.handle.net/2440/7859
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dc.contributor.author | Howarth, G. | - |
dc.contributor.author | Xian, C. | - |
dc.contributor.author | Read, L. | - |
dc.date.issued | 1998 | - |
dc.identifier.citation | Scandinavian Journal of Gastroenterology, 1998; 33(2):180-190 | - |
dc.identifier.issn | 0036-5521 | - |
dc.identifier.issn | 1502-7708 | - |
dc.identifier.uri | http://hdl.handle.net/2440/7859 | - |
dc.description.abstract | <h4>Background</h4>Administration of insulin-like growth factor-I (IGF-I) results in selective growth of the gastrointestinal tract. We investigated the effects of IGF-I on the colonic damage induced by oral dextran sulphate sodium (DSS) in the rat.<h4>Methods</h4>Rats consumed 2% DSS in the drinking water for 10 days to induce colitis. Pumps were implanted on day 3 to deliver IGF-I for 7 days. Colonic histopathology and immunolocalization of transforming growth factor-beta1 (TGF-beta1) were assessed on day 10.<h4>Results</h4>Compared with the colon of vehicle-treated rats consuming DSS, IGF-I increased the numbers of goblet cells by 76%, reduced the proportion of lamina propria cells expressing TGF-beta1, and reduced the thickness of submucosal and muscularis externa layers by 26% and 20%, respectively.<h4>Conclusions</h4>We conclude that the effects of IGF-I treatment on the colonic epithelium may be mediated directly, whereas the reduced inflammation in the mucosa and submucosa may be mediated by a mechanism other than up-regulation of TGF-beta1-mediated immunosuppression. | - |
dc.language.iso | en | - |
dc.publisher | TAYLOR & FRANCIS LTD | - |
dc.source.uri | http://dx.doi.org/10.1080/00365529850166923 | - |
dc.subject | Intestinal Mucosa | - |
dc.subject | Colon | - |
dc.subject | Animals | - |
dc.subject | Rats | - |
dc.subject | Rats, Sprague-Dawley | - |
dc.subject | Colitis, Ulcerative | - |
dc.subject | Body Weight | - |
dc.subject | Dextran Sulfate | - |
dc.subject | Transforming Growth Factor beta | - |
dc.subject | Insulin-Like Growth Factor I | - |
dc.subject | Organ Size | - |
dc.subject | Immunohistochemistry | - |
dc.subject | Dose-Response Relationship, Drug | - |
dc.subject | Male | - |
dc.title | Insulin-like growth factor-I partially attenuates colonic damage in rats with experimental colitis induced by oral dextran sulphate sodium | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1080/00365529850166923 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Howarth, G. [0000-0001-6979-6084] | - |
dc.identifier.orcid | Xian, C. [0000-0002-8467-2845] | - |
Appears in Collections: | Aurora harvest 4 Paediatrics publications |
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