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https://hdl.handle.net/2440/78984
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dc.contributor.author | Harvey, G. | - |
dc.contributor.author | Fitzsimmons, T. | - |
dc.contributor.author | Dharmapatni, A. | - |
dc.contributor.author | Marchant, C. | - |
dc.contributor.author | Haynes, D. | - |
dc.contributor.author | Bartold, P. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Periodontal Research, 2013; 48(2):252-261 | - |
dc.identifier.issn | 0022-3484 | - |
dc.identifier.issn | 1600-0765 | - |
dc.identifier.uri | http://hdl.handle.net/2440/78984 | - |
dc.description.abstract | BACKGROUND AND OBJECTIVE The presence of citrullinated proteins, and peptidylarginine deiminase types -2 (PAD-2) and -4 (PAD-4) in periodontal tissues, determine the presence of anti-cyclic citrullinated protein antibodies (anti-CCP) in gingival crevicular fluid (GCF) and compare the expression of these proteins between inflamed and non-inflamed sites. MATERIAL AND METHODS Tissue sections were stained using antibodies against citrullinated proteins, PAD-2 and PAD-4. RT-PCR was performed to investigate PAD-2 and PAD-4 mRNA in inflamed and non-inflamed gingival tissues. Anti-CCP antibodies in gingival crevicular fluid were detected by ELISA. RESULTS Citrullinated proteins, PAD-2 and PAD-4 were detected in gingiva. There was a correlation between inflammation and expression of these proteins. mRNAs for PAD-2 and PAD-4 were detected in both inflamed and non-inflamed gingival tissues. Antibodies to CCP were found mostly in the GCF of individuals with periodontitis. Conclusion PAD-2 and PAD-4 (protein and mRNA) as well as citrullinated proteins are present in inflamed gingiva, and anti-CCP antibodies can be detected in the GCF of some patients. Tissue expression of citrullinated proteins and PAD increased with the severity of inflammation. The presence of anti-CCP antibodies in GCF was almost exclusive to a subset of patients with periodontitis. Increased expression of these proteins in inflamed gingiva lends support to the notion that periodontal inflammation contributes to the inflammatory burden in a similar way to rheumatoid arthritis. | - |
dc.description.statementofresponsibility | G. P. Harvey, T. R. Fitzsimmons, A. A. S. S. K. Dhamarpatni, C. Marchant, D. R. Haynes, P. M. Bartold | - |
dc.language.iso | en | - |
dc.publisher | Blackwell Munksgaard | - |
dc.rights | © 2012 John Wiley & Sons A/S | - |
dc.source.uri | http://dx.doi.org/10.1111/jre.12002 | - |
dc.subject | anti-citrullinated proteins | - |
dc.subject | chronic inflammation | - |
dc.subject | citrullination | - |
dc.subject | periodontitis | - |
dc.subject | rheumatoid arthritis | - |
dc.title | Expression of peptidylarginine deiminase-2 and -4, citrullinated proteins and anti-citrullinated protein antibodies in human gingiva | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/jre.12002 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Fitzsimmons, T. [0000-0002-1029-8352] | - |
dc.identifier.orcid | Bartold, P. [0000-0002-5695-3877] [0000-0002-6225-3084] | - |
Appears in Collections: | Aurora harvest 4 Dentistry publications |
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