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https://hdl.handle.net/2440/79044
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dc.contributor.author | Zhou, C. | - |
dc.contributor.author | Yool, A. | - |
dc.contributor.author | Byard, R. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Forensic Sciences, 2013; 58(3):693-696 | - |
dc.identifier.issn | 0022-1198 | - |
dc.identifier.issn | 1556-4029 | - |
dc.identifier.uri | http://hdl.handle.net/2440/79044 | - |
dc.description.abstract | Renal cortical pallor was studied as a potential marker at autopsy of diabetic ketoacidosis in 23 cases, hyperglycemic nonketotic coma in eight cases, and alcoholic ketoacidosis in five cases (vitreous humor glucose level≥11.1 mM; β-hydroxybutyrate level≥5 mM). Renal cortical pallor was noted on macroscopic examination in 10 of 23 cases of lethal diabetic ketoacidosis (43.5%), three of eight cases of fatal hyperglycemic nonketotic coma (37.5%), and in two of five cases of alcoholic ketoacidosis (40%). Histologic examination revealed basal vacuolization of renal tubular epithelial cells in 12 cases, Armanni-Ebstein lesions in 10, and osmotic nephrosis in three. Although renal cortical pallor did not appear to be a particularly sensitive marker for hyperglycemia or ketoacidosis, and did not correlate with the severity of these parameters, it may still represent a useful macroscopic marker for underlying metabolic conditions at autopsy and should therefore prompt measurement of vitreous humor glucose and β-hydroxybutyrate levels. | - |
dc.description.statementofresponsibility | Chong Zhou, Andrea Yool, and Roger W. Byard | - |
dc.language.iso | en | - |
dc.publisher | Amer Soc Testing Materials | - |
dc.rights | © 2013 American Academy of Forensic Sciences | - |
dc.source.uri | http://dx.doi.org/10.1111/1556-4029.12102 | - |
dc.subject | forensic science | - |
dc.subject | renal cortical pallor | - |
dc.subject | ketoacidosis | - |
dc.subject | diabetes mellitus | - |
dc.subject | alcoholism | - |
dc.subject | hyperglycemia | - |
dc.subject | epithelial vacuolization | - |
dc.subject | Armanni–Ebstein | - |
dc.title | Renal cortical pallor - a useful macroscopic marker for metabolic derangements at autopsy | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1111/1556-4029.12102 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Yool, A. [0000-0003-1283-585X] | - |
dc.identifier.orcid | Byard, R. [0000-0002-0524-5942] | - |
Appears in Collections: | Aurora harvest 4 Pathology publications |
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