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https://hdl.handle.net/2440/7928
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Type: | Journal article |
Title: | Emergence of altered circadian timing in a cholinergically supersensitive rat line |
Author: | Ferguson, S. Kennaway, D. |
Citation: | American Journal of Physiology: Regulatory, Integrative and Comparative Physiology, 1999; 277(4 46-4):R1171-R1178 |
Publisher: | AMER PHYSIOLOGICAL SOC |
Issue Date: | 1999 |
ISSN: | 0363-6119 2163-5773 |
Abstract: | Mammalian circadian rhythms are controlled by the suprachiasmatic nuclei (SCN) in concert with light information. Several neurotransmitters and neural pathways modulate light effects on SCN timing. This study used a line of rat with an upregulated cholinergic system to investigate the role of acetylcholine in rhythmicity. With the use of a selective breeding program based on the thermic response to a cholinergic agonist, we developed a supersensitive (S(ox)) and subsensitive (R(ox)) rat line. The S(ox) rats showed an earlier onset time of melatonin rhythm under a 12:12-h light-dark photoperiod from generation 3 (3 +/- 0.5 h after dark) compared with R(ox) rats (4.5 +/- 0.1 h) and an earlier morning decline in temperature (0.9 +/- 0.3 h before lights on) compared with R(ox) animals (0.1 +/- 0.1 h). Furthermore, the S(ox) animals displayed a significantly shorter free-running period of temperature rhythm than R(ox) rats (23.9 +/- 0.04 and 24.3 +/- 0.1 h, respectively, P < 0.05). The results suggest that the altered circadian timing of the S(ox) rats may be related to the cholinergic supersensitivity, intimating a role for acetylcholine in the circadian timing system. |
Keywords: | Suprachiasmatic Nucleus Animals Rats Acetylcholine Oxotremorine Melatonin Proto-Oncogene Proteins c-fos Cholinergic Agents Muscarinic Agonists Body Temperature Circadian Rhythm Drug Resistance Light Darkness |
DOI: | 10.1152/ajpregu.1999.277.4.r1171 |
Published version: | http://dx.doi.org/10.1152/ajpregu.1999.277.4.r1171 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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