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https://hdl.handle.net/2440/7957
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Type: | Journal article |
Title: | Calcium channel blockers for inhibiting preterm labour; a systematic review of the evidence and a protocol for administration of nifedipine |
Author: | King, J. Flenady, V. Papatsonis, D. Dekker, G. Carbonne, B. |
Citation: | Australian and New Zealand Journal of Obstetrics and Gynaecology, 2003; 43(3):192-198 |
Publisher: | Australian NZ J Obstet Gynaec |
Issue Date: | 2003 |
ISSN: | 0004-8666 1479-828X |
Statement of Responsibility: | James F. King, Vicki Flenady, Dimitri Papatsonis, Gustaaf Dekker, Bruno Carbonne |
Abstract: | Objective: To assess the effects on maternal, fetal and neonatal outcomes of nifedipine (and other calcium channel blockers) administered as a tocolytic agent to women in preterm labour. Methods: Standard methods of the Cochrane Collaboration and its Pregnancy and Childbirth Review Group were used. All published and unpublished randomised trials in which calcium channel blockers were used for tocolysis for women in preterm labour between 20 and 36 weeks’ gestation, were considered. Main results: The systematic review includes 12 randomised controlled trials with a total of 1029 participating women. No trials were identified in which calcium channel blockers were compared with a placebo or no alternative tocolytic treatment. Calcium channel blockers appear to be more effective than betamimetic agents in prolonging pregnancy for 7 days or longer, are much less likely to cause maternal side-effects and are associated with reduced neonatal morbidity. Conclusion: Calcium channel blockers (especially nifedipine) can be considered safer and more effective tocolytic agents than betamimetics. |
Keywords: | Humans Nifedipine Calcium Channel Blockers Placebos Pregnancy Outcome Clinical Protocols Pregnancy Female Obstetric Labor, Premature Randomized Controlled Trials as Topic Contraindications Systematic Reviews as Topic |
Description: | The definitive version is available at www.blackwell-synergy.com |
DOI: | 10.1046/j.0004-8666.2003.00074.x |
Published version: | http://dx.doi.org/10.1046/j.0004-8666.2003.00074.x |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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