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https://hdl.handle.net/2440/7987
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Type: | Journal article |
Title: | Haematopoietic indicators of fetal metabolic acidosis |
Author: | Spencer, M. Khong, T. Matthews, B. MacLennan, A. |
Citation: | Australian and New Zealand Journal of Obstetrics and Gynaecology, 2000; 40(3):286-289 |
Publisher: | Blackwell Publishing Asia |
Issue Date: | 2000 |
ISSN: | 0004-8666 1479-828X |
Abstract: | We aimed to study the haematopoietic response in normal and acidotic deliveries following vaginal and abdominal delivery and to compare this to the surrogate markers of perinatal acidosis. Blood gas analyses, complete blood pictures and erythropoietin assays were performed on umbilical or early neonatal blood samples. Placental sections were examined for the presence of nucleated red blood cells. Perinatal clinical risk factors and major neonatal outcomes were collected. The control population was 78 deliveries where the cord arterial pH was > 7.10. Controls born after labour were compared to those born prior to the onset of labour and to 14 acidotic infants born after labour. Nucleated red blood cells did not increase with labour in the control groups but were significantly higher (p < 0.05) in the acidotic group. Erythropoietin did not significantly change with either labour or acidosis. The predictive values from nucleated red blood cell counts were higher than those from low Apgar scores, atypical cardiotocograph traces, meconium-stained amniotic fluid, erythropoietin and the presence of nucleated red blood cells in placental sections. Nucleated red blood cell counts may be a useful surrogate marker of acidosis where blood gas analysis is unavailable. Further studies are required to examine the timing of the increase of erythropoiesis to help define the onset of the stimulus. |
Keywords: | Fetal Blood Humans Fetal Diseases Asphyxia Neonatorum Acidosis Erythropoietin Fetal Monitoring Blood Gas Analysis Erythrocyte Count Pregnancy Outcome Delivery, Obstetric Probability Sensitivity and Specificity Chi-Square Distribution Hematopoiesis Pregnancy Hydrogen-Ion Concentration Reference Values Infant, Newborn Female Obstetric Labor Complications |
DOI: | 10.1111/j.1479-828X.2000.tb03336.x |
Published version: | http://dx.doi.org/10.1111/j.1479-828x.2000.tb03336.x |
Appears in Collections: | Aurora harvest 4 Obstetrics and Gynaecology publications |
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