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https://hdl.handle.net/2440/80330
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Type: | Journal article |
Title: | Border patrol intensifies for hepatitis C virus entry |
Author: | McCartney, E. Eyre, N. Beard, M. |
Citation: | Hepatology, 2011; 54(4):1472-1475 |
Publisher: | John Wiley & Sons Inc |
Issue Date: | 2011 |
ISSN: | 0270-9139 1527-3350 |
Editor: | Kowdley, K. McCaughan, G. Trautwein, C. |
Statement of Responsibility: | Erin M. Mccartney, Nicholas S. Eyre, Michael R. Beard |
Abstract: | Hepatitis C virus (HCV) is a major cause of liver disease, but therapeutic options are limited and there are no prevention strategies. Viral entry is the first step of infection and requires the cooperative interaction of several host cell factors. Using a functional RNAi kinase screen, we identified epidermal growth factor receptor and ephrin receptor A2 as host cofactors for HCV entry. Blocking receptor kinase activity by approved inhibitors broadly impaired infection by all major HCV genotypes and viral escape variants in cell culture and in a human liver chimeric mouse model in vivo. The identified receptor tyrosine kinases (RTKs) mediate HCV entry by regulating CD81-claudin-1 coreceptor associations and viral glycoprotein-dependent membrane fusion. These results identify RTKs as previously unknown HCV entry cofactors and show that tyrosine kinase inhibitors have substantial antiviral activity. Inhibition of RTK function may constitute a new approach for prevention and treatment of HCV infection. © 2011 American Association for the Study of Liver Diseases. |
Rights: | Copyright © 2011 American Association for the Study of Liver Diseases |
DOI: | 10.1002/hep.24586 |
Published version: | http://dx.doi.org/10.1002/hep.24586 |
Appears in Collections: | Aurora harvest 4 Molecular and Biomedical Science publications |
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