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https://hdl.handle.net/2440/81327
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dc.contributor.author | Antony, S. | - |
dc.contributor.author | Aitken, J. | - |
dc.contributor.author | Vogt, S. | - |
dc.contributor.author | Lai, B. | - |
dc.contributor.author | Brown, T. | - |
dc.contributor.author | Spiccia, L. | - |
dc.contributor.author | Harris, H. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Biological Inorganic Chemistry, 2013; 18(7):845-853 | - |
dc.identifier.issn | 0949-8257 | - |
dc.identifier.issn | 1432-1327 | - |
dc.identifier.uri | http://hdl.handle.net/2440/81327 | - |
dc.description.abstract | Analogues of KP1019 containing iodinated indazole ligands were prepared to investigate the biological fate of the Ru-N-heterocycle bond in this class of anticancer agents. The new complexes, 5-iodoindazolium trans-tetrachloridobis(5-iodoindazole)ruthen(III)ate (1) and 5-iodoindazolium trans-tetrachlorido(dimethyl sulfoxide)(5-iodoindazole)ruthen(III)ate (3), were characterized by elemental analysis, mass spectrometry and UV-vis spectrophotometry. Tetramethylammonium salts of these complexes (2 and 4) were synthesized and characterized in a similar manner. Half-maximum inhibitory concentrations of 2 and 4 with regard to A549 cells at 24 h were determined on the basis of the dose-response curves derived from real-time cell adhesion impedance measurements and were shown to be in the same range as those determined for KP1019 and NAMI-A using the same method. X-ray fluorescence imaging of single cultured A549 cells treated with 2 or 4 showed that, in both cases, the distribution of ruthenium and iodine was identical, indicating that the Ru-N bonds in the anionic complexes remained intact after incubation in culture medium and subsequent cellular uptake and processing. | - |
dc.description.statementofresponsibility | Sumy Antony, Jade B. Aitken, Stefan Vogt, Barry Lai, Tracey Brown, Leone Spiccia, Hugh H. Harris | - |
dc.language.iso | en | - |
dc.publisher | Springer-Verlag | - |
dc.rights | © SBIC 2013 | - |
dc.source.uri | http://dx.doi.org/10.1007/s00775-013-1027-z | - |
dc.subject | Anticancer drugs | - |
dc.subject | Ruthenium | - |
dc.subject | Iodine | - |
dc.subject | X-ray fluorescence imaging | - |
dc.title | X-ray fluorescence imaging of single human cancer cells reveals that the N-heterocyclic ligands of iodinated analogues of ruthenium anticancer drugs remain coordinated after cellular uptake | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1007/s00775-013-1027-z | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0985807 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0984722 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Harris, H. [0000-0002-3472-8628] | - |
Appears in Collections: | Aurora harvest Chemistry and Physics publications |
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