Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/81417
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Type: | Journal article |
Title: | Modulation of individual components of gastric motor response to duodenal glucose |
Author: | Deane, A. Besanko, L. Burgstad, C. Chapman, M. Horowitz, M. Fraser, R. |
Citation: | World Journal of Gastroenterology, 2013; 19(35):5863-5869 |
Publisher: | W J G Press |
Issue Date: | 2013 |
ISSN: | 1007-9327 2219-2840 |
Statement of Responsibility: | Adam M Deane, Laura K Besanko, Carly M Burgstad, Marianne J Chapman, Michael Horowitz, Robert JL Fraser |
Abstract: | AIM: To evaluate individual components of the antro-pyloro-duodenal (APD) motor response to graded small intestinal glucose infusions in healthy humans. METHODS: APD manometry was performed in 15 healthy subjects (12 male; 40 ± 5 years, body mass index 26.5 ± 1.6 kg/m2) during four 20-min intraduodenal infusions of glucose at 0, 0.5, 1.0 and 1.5 kcal/min, in a randomised double-blinded fashion. Glucose solutions were infused at a rate of 1 mL/min and separated by 40-min “wash-out” period. Data are mean ± SE. Inferential analyses are repeated measure analysis of variance with Bonferroni post-hoc testing. RESULTS: At 0 kcal/min frequency of pressure waves were: antrum (7.5 ± 1.8 waves/20 min) and isolated pyloric pressure waves (IPPWs) (8.0 ± 2.3 waves/20 min) with pyloric tone (0.0 ± 0.9 mmHg). Intraduodenal glucose infusion acutely increased IPPW frequency (P < 0.001) and pyloric tone (P = 0.015), and decreased antral wave frequency (P = 0.007) in a dose-dependent fashion. A threshold for stimulation was observed at 1.0 kcal/min for pyloric phasic pressure waves (P = 0.002) and 1.5 kcal/min for pyloric tone and antral contractility. CONCLUSION: There is hierarchy for the activation of gastrointestinal motor responses to duodenal glucose infusion. An increase in IPPWs is the first response observed. |
Keywords: | Glucose Gastrointestinal motility Pyloric Antral Duodenum Manometry Motor activity Blood glucose |
Rights: | ©2013 Baishideng Publishing Group Co., Limited. All rights reserved. |
DOI: | 10.3748/wjg.v19.i35.5863 |
Published version: | http://dx.doi.org/10.3748/wjg.v19.i35.5863 |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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hdl_81417.pdf | Published version | 1.2 MB | Adobe PDF | View/Open |
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