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https://hdl.handle.net/2440/81509
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Type: | Journal article |
Title: | Regional resistance surveillance program results for 12 Asia-Pacific nations (2011) |
Author: | Mendes, R. Mendoza, M. Banga Singh, K. Castanheira, M. Bell, J. Turnidge, J. Lin, S. Jones, R. |
Citation: | Antimicrobial Agents and Chemotherapy, 2013; 57(11):5721-5726 |
Publisher: | Amer Soc Microbiology |
Issue Date: | 2013 |
ISSN: | 0066-4804 1098-6596 |
Statement of Responsibility: | Rodrigo E. Mendes, Myrna Mendoza, Kirnpal K. Banga Singh, Mariana Castanheira, Jan M. Bell, John D. Turnidge, Stephen S. F. Lin, Ronald N. Jones |
Abstract: | The Regional Resistance Surveillance program monitored susceptibility rates and developing resistance by geographic region, including 12 Asia-Pacific (APAC) countries. Reference broth microdilution methods for susceptibility/interpretations were applied, processing 5,053 strains. Among Staphylococcus aureus isolates (37% methicillin-resistant S. aureus [MRSA], highest in South Korea [73%]), linezolid (LZD), tigecycline (TIG), and vancomycin were 100% active, but 33 and 34% of strains were levofloxacin (LEV) or macrolide resistant, respectively. Streptococcus pneumoniae was most resistant to β-lactams and macrolides (45%) but was LZD, LEV, and TIG susceptible (>98%). Extended-spectrum β-lactamase (ESBL) phenotype rates in Escherichia coli and Klebsiella spp. were 48 and 47%, respectively, and were highest in Taiwan, at 75 to 91%. The best anti-ESBL-phenotype agents were amikacin (81 to 96% susceptible), colistin (COL; >98%), TIG (>98%), and carbapenems (81 to 97%). Pseudomonas aeruginosa showed ≥20% resistance to all drugs except COL (99% susceptible). In conclusion, endemic evolving antimicrobial resistances in APAC nations show compromised roles for many commonly used antimicrobials. |
Keywords: | Humans Pseudomonas aeruginosa Escherichia coli Klebsiella Staphylococcus aureus Streptococcus pneumoniae Gram-Negative Bacterial Infections Gram-Positive Bacterial Infections Anti-Bacterial Agents Microbial Sensitivity Tests Drug Resistance, Multiple, Bacterial Asia Australia New Zealand Epidemiological Monitoring |
Rights: | Copyright © 2013, American Society for Microbiology. All Rights Reserved. |
DOI: | 10.1128/AAC.01121-13 |
Published version: | http://dx.doi.org/10.1128/aac.01121-13 |
Appears in Collections: | Aurora harvest Molecular and Biomedical Science publications |
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