Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/8171
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Leptin alters the structural and functional characteristics of adipose tissue before birth |
Author: | Yuen, B. Owens, P. Muhlhausler, B. Roberts, C. Symonds, M. Keisler, D. McFarlane, J. Kauter, K. Evens, Y. McMillen, I. |
Citation: | The FASEB Journal, 2003; 17(6):www 1-www 22 |
Publisher: | Federation Amer Soc Exp Biol |
Issue Date: | 2003 |
ISSN: | 0892-6638 1530-6860 |
Statement of Responsibility: | B. S. J. Yuen, P. C. Owens, B. S. Muhlhausler, C. T. Roberts, M. E. Symonds, D. H. Keisler, J. R. McFarlane, K. G. Kauter, Y. Evens, and I. C. McMillen |
Abstract: | This study aimed to determine for the first time whether leptin can act to alter the structural and functional characteristics of adipose tissue before birth. Leptin (0.48 mg/kg/day) or saline was infused intravenously into fetal sheep for 4 days from either 136 or 137 days of gestation (term=147±3 days). Circulating leptin concentrations were increased approximately four- to fivefold by leptin infusion. Leptin infusion resulted in a significant increase in the proportion of smaller lipid locules present within fetal perirenal adipose tissue (PAT), and this was associated with a significant increase in the proportion of multilocular tissue and a significant decrease in the proportion and relative mass of unilocular tissue in fetal PAT. The relative abundance of leptin mRNA in fetal PAT was significantly lower in the leptin-infused group, and there was a positive correlation between the relative abundance of leptin mRNA and the proportion of unilocular adipose tissue in fetal PAT. The amount of uncoupling protein 1 tended to be higher (P=0.06) in leptin-infused compared with saline-infused fetuses. This is the first demonstration that leptin can act to regulate the lipid storage characteristics, leptin synthetic capacity, and potential thermogenic functions of fat before birth. |
Keywords: | fetus lipid UCP1 |
Rights: | © Federation of American Societies for Experimental Biology |
DOI: | 10.1096/fj.02-0756fje |
Grant ID: | NHMRC |
Published version: | http://dx.doi.org/10.1096/fj.02-0756fje |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.