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https://hdl.handle.net/2440/82052
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DC Field | Value | Language |
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dc.contributor.author | Finnie, J. | - |
dc.contributor.author | Blumbergs, P. | - |
dc.contributor.author | Manavis, J. | - |
dc.contributor.author | Vink, R. | - |
dc.date.issued | 2013 | - |
dc.identifier.citation | Journal of Clinical Neuroscience, 2013; 20(12):1759-1761 | - |
dc.identifier.issn | 0967-5868 | - |
dc.identifier.issn | 1532-2653 | - |
dc.identifier.uri | http://hdl.handle.net/2440/82052 | - |
dc.description.abstract | Expression of the immediate early gene, c-fos, was examined in a large animal model of non-accidental head injury ("shaken baby syndrome"). Lambs were used because they have a relatively large gyrencephalic brain and weak neck muscles resembling a human infant. Neonatal lambs were manually shaken in a manner similar to that believed to occur with most abused human infants, but there was no head impact. The most striking c-fos expression was in meningothelial cells of the cranial cervical spinal cord and, to a lesser degree, in hemispheric, cerebellar, and brainstem meninges. Vascular endothelial cells also frequently showed c-fos immunopositivity in the meninges and hemispheric white matter. It was hypothesised that this c-fos immunoreactivity was due to mechanical stress induced by shaking, with differential movement of different craniospinal components. | - |
dc.description.statementofresponsibility | J.W. Finnie, P.C. Blumbergs, J. Manavis, R. Vink | - |
dc.language.iso | en | - |
dc.publisher | Churchill Livingstone | - |
dc.rights | Crown copyright © 2013 | - |
dc.source.uri | http://dx.doi.org/10.1016/j.jocn.2013.03.010 | - |
dc.subject | Animal model | - |
dc.subject | c-fos expression | - |
dc.subject | Non-accidental head injury | - |
dc.title | Pattern of cerebrospinal immediate early gene c-fos expression in an ovine model of non-accidental head injury | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.jocn.2013.03.010 | - |
dc.relation.grant | NHMRC | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Finnie, J. [0000-0003-2277-1693] | - |
dc.identifier.orcid | Vink, R. [0000-0002-4885-0667] | - |
Appears in Collections: | Aurora harvest 4 Medical Sciences publications |
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