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https://hdl.handle.net/2440/8425
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Type: | Journal article |
Title: | Polymorphisms in the tumor necrosis factor and lymphotoxin-a gene region and preeclampsia |
Author: | Lachmeijer, A. Crusius, J. Pals, G. Dekker, G. Arngrimsson, R. ten Kate, L. |
Citation: | Obstetrics and Gynecology, 2001; 98(4):612-619 |
Publisher: | Elsevier Science Inc |
Issue Date: | 2001 |
ISSN: | 0029-7844 1873-233X |
Abstract: | OBJECTIVE: To investigate potential association or linkage among nine polymorphisms in the genes encoding tumor necrosis factor (TNF) or lymphotoxin (LT) and preeclampsia. METHODS: Four di-allelic polymorphisms and five microsatellite markers in the genes encoding TNF- (TNF) and LT (LTA) and their haplotypes were studied in 150 Dutch families. These families contained sib-pairs of women affected with preeclampsia; eclampsia; the hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome (strict criteria); or pregnancy-induced hypertension (mild criteria). Frequencies were compared with 98 healthy controls. Nonparametric affected sib-pair analyses for allele sharing among siblings were carried out for all nine markers. Each sibship was composed of an affected index woman and one or more affected sisters. RESULTS: Although we found a striking association with the TNF-I haplotype in 30 index women with (pre-)eclampsia or HELLP syndrome compared with controls (odds ratio [OR] 3.8; 95% confidence interval [CI] 1.6, 8.9), this association was not found in their 30 sisters meeting similar disease criteria. Analyses in all 150 families showed a similar TNF-I association in 122 index women meeting the strict criteria compared with controls (OR 1.9; 95% CI 1.1, 3.3), but, again, not in their 91 sisters meeting similar disease criteria. This association was stronger in a subgroup of 75 index women with preeclampsia only (OR 2.3; 95% CI 1.2, 4.2). No excess allele sharing for any marker was seen between the siblings. CONCLUSION: The nine polymorphisms studied in the TNF-LTA region did not show evidence for association or linkage with familial preeclampsia. |
Keywords: | Humans Eclampsia HELLP Syndrome Pre-Eclampsia Tumor Necrosis Factor-alpha Case-Control Studies Pilot Projects Microsatellite Repeats Pregnancy Haplotypes Lod Score Polymorphism, Genetic Female Lymphotoxin-alpha |
Description: | © 2001 by The American College of Obstetricians and Gynecologists |
DOI: | 10.1016/S0029-7844(01)01487-9 |
Published version: | http://www.greenjournal.org/cgi/content/abstract/98/4/612 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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