Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/84492
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DC Field | Value | Language |
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dc.contributor.author | Liu, Y. | - |
dc.contributor.author | Carver, J. | - |
dc.contributor.author | Calabrese, A. | - |
dc.contributor.author | Pukala, T. | - |
dc.date.issued | 2014 | - |
dc.identifier.citation | BBA: Proteins and Proteomics, 2014; 1844(9):1481-1485 | - |
dc.identifier.issn | 1878-1454 | - |
dc.identifier.issn | 1878-1454 | - |
dc.identifier.uri | http://hdl.handle.net/2440/84492 | - |
dc.description.abstract | The accumulation of protein aggregates containing amyloid fibrils, with α-synuclein being the main component, is a pathological hallmark of Parkinson's disease (PD). Molecules which prevent the formation of amyloid fibrils or disassociate the toxic aggregates are touted as promising strategies to prevent or treat PD. In the present study, in vitro Thioflavin T fluorescence assays and transmission electron microscopy imaging results showed that gallic acid (GA) potently inhibits the formation of amyloid fibrils by α-synuclein. Ion mobility-mass spectrometry demonstrated that GA stabilises the extended, native structure of α-synuclein, whilst NMR spectroscopy revealed that GA interacts with α-synuclein transiently. | - |
dc.description.statementofresponsibility | Yanqin Liu, John A. Carver, Antonio N. Calabrese, Tara L. Pukala | - |
dc.language.iso | en | - |
dc.publisher | Elsevier B.V. | - |
dc.rights | Copyright © 2014 Elsevier B.V. | - |
dc.source.uri | http://dx.doi.org/10.1016/j.bbapap.2014.04.013 | - |
dc.subject | α-Synuclein; Amyloid fibril; Gallic acid; NMR spectroscopy; Ion mobility mass spectrometry | - |
dc.title | Gallic acid interacts with α-synuclein to prevent the structural collapse necessary for its aggregation | - |
dc.title.alternative | Gallic acid interacts with alpha-synuclein to prevent the structural collapse necessary for its aggregation | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1016/j.bbapap.2014.04.013 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP1093143 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Pukala, T. [0000-0001-7391-1436] | - |
Appears in Collections: | Aurora harvest 2 Chemistry and Physics publications |
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