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https://hdl.handle.net/2440/8451
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Type: | Journal article |
Title: | CD83+ dendritic cells in the decidua of women with recurrent miscarriage and normal pregnancy |
Author: | Askelund, K. Liddell, H. Zanderigo, A. Fernando, N. Khong, T. Stone, P. Chamley, L. |
Citation: | Placenta, 2004; 25(2-3):140-145 |
Publisher: | W B Saunders Co Ltd |
Issue Date: | 2004 |
ISSN: | 0143-4004 1532-3102 |
Abstract: | Immunological factors have been postulated to play a role in the aetiology of recurrent miscarriage as the fetus and placenta are semi-allogenic to the mother. Potent immunostimulatory (CD83(+)) dendritic cells have recently been identified in the uterine decidua. This study was conducted to examine whether decidual dendritic cells could play a role in the aetiology of recurrent miscarriage. First trimester placental and decidual biopsies were obtained from 40 women with recurrent miscarriage and 15 gestation-matched normal controls. These biopsies were screened by immunohistochemistry for CD83(+)cells. Staining was analysed by light microscopy and digital image analysis. In both recurrent miscarriage and normal pregnancy, CD83(+)dendritic cells were localized to the decidua. Individual dendritic cells were present in the decidual stroma or in clusters of 3-4 dendritic cells, in lymphoid aggregates. There were no significant differences in decidual CD83(+)dendritic cell density between women with recurrent miscarriage and normal pregnancy when the groups were compared as a whole. However, when segregated by gestational age, decidua from women with recurrent miscarriage at 8 weeks' gestation contained significantly more dendritic cells than gestational age-matched normal controls. This suggests dendritic cells may play a role in the aetiology of some cases of recurrent miscarriage. |
Keywords: | Decidua Dendritic Cells Humans Abortion, Habitual Immunoglobulins Membrane Glycoproteins Antigens, CD Fluorescent Antibody Technique, Indirect Pregnancy Pregnancy Trimester, First Adult Female |
DOI: | 10.1016/S0143-4004(03)00182-6 |
Published version: | http://dx.doi.org/10.1016/s0143-4004(03)00182-6 |
Appears in Collections: | Aurora harvest Obstetrics and Gynaecology publications |
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