Adelaide Research & Scholarship
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https://hdl.handle.net/2440/84751
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| Type: | Journal article |
| Title: | Uncovering GPCR heteromer-biased ligands |
| Author: | Mustafa, S. Ayoub, M. Pfleger, K. |
| Citation: | Drug Discovery Today: Technologies, 2010; 7(1):e77-e85 |
| Publisher: | Elsevier |
| Issue Date: | 2010 |
| ISSN: | 1740-6749 |
| Statement of Responsibility: | Sanam Mustafa, Mohammed Akli Ayoub, Kevin D.G. Pfleger |
| Abstract: | The formation of complexes involving different G-protein-coupled receptors (GPCRs) is now an established phenomenon, termed heteromerization. The relevance of higher order structures, in particular heteromerization, has been demonstrated by differential pharmacology displayed by GPCR heteromers compared to monomers/homomers of the respective constituent receptor units. The concepts of heteromerization and heteromer-selective/biased ligands introduce exciting opportunities for enhancing signal specificity and therefore have the potential to play a crucial role in future drug discovery. © 2010 Elsevier Ltd. All rights reserved. |
| Rights: | © 2010 Elsevier Ltd. |
| DOI: | 10.1016/j.ddtec.2010.06.003 |
| Published version: | http://dx.doi.org/10.1016/j.ddtec.2010.06.003 |
| Appears in Collections: | Aurora harvest 7 Physiology publications |
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