Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/85214
Citations | ||
Scopus | Web of Science® | Altmetric |
---|---|---|
?
|
?
|
Type: | Journal article |
Title: | Exercise as an intervention to improve metabolic outcomes after intrauterine growth restriction |
Author: | Gatford, K. Kaur, G. Falcao-Tebas, F. Wadley, G. Wlodek, M. Laker, R. Ebeling, P. McConell, G. |
Citation: | American Journal of Physiology: Endocrinology and Metabolism, 2014; 306(9):E999-E1012 |
Publisher: | American Physiological Society |
Issue Date: | 2014 |
ISSN: | 0193-1849 1522-1555 |
Statement of Responsibility: | Kathryn L. Gatford, Gunveen Kaur, Filippe Falcão-Tebas, Glenn D. Wadley, Mary E. Wlodek, Rhianna C. Laker, Peter R Ebeling, Glenn K. McConell |
Abstract: | Individuals born after intrauterine growth restriction (IUGR) are at an increased risk of developing diabetes in their adult life. IUGR impairs β-cell function and reduces β-cell mass, thereby diminishing insulin secretion. IUGR also induces insulin resistance, with impaired insulin signaling in muscle in adult humans who were small for gestational age (SGA) and in rodent models of IUGR. There is epidemiological evidence in humans that exercise in adults can reduce the risk of metabolic disease following IUGR. However, it is not clear whether adult IUGR individuals benefit to the same extent from exercise as do normal-birth-weight individuals, as our rat studies suggest less of a benefit in those born IUGR. Importantly, however, there is some evidence from studies in rats that exercise in early life might be able to reverse or reprogram the long-term metabolic effects of IUGR. Studies are needed to address gaps in current knowledge, including determining the mechanisms involved in the reprogramming effects of early exercise in rats, whether exercise early in life or in adulthood has similar beneficial metabolic effects in larger animal models in which insulin resistance develops after IUGR. Human studies are also needed to determine whether exercise training improves insulin secretion and insulin sensitivity to the same extent in IUGR adults as in control populations. Such investigations will have implications for customizing the recommended level and timing of exercise to improve metabolic health after IUGR. |
Keywords: | IUGR; glucose tolerance; insulin secretion; -cells; insulin sensitivity; training; physical activit |
Rights: | Copyright © 2014 the American Physiological Society |
DOI: | 10.1152/ajpendo.00456.2013 |
Published version: | http://dx.doi.org/10.1152/ajpendo.00456.2013 |
Appears in Collections: | Aurora harvest 7 Paediatrics publications |
Files in This Item:
There are no files associated with this item.
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.