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https://hdl.handle.net/2440/8587
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Type: | Journal article |
Title: | Appetite regulation by carbohydrate: role of blood glucose and gastrointestinal hormones. |
Author: | Lavin, J. Wittert, G. Sun, W.M. Horowitz, M. Morley, J. Read, N. |
Citation: | American Journal of Physiology: Endocrinology and Metabolism, 1996; 271(2 34-2):E209-E214 |
Publisher: | AMER PHYSIOLOGICAL SOC |
Issue Date: | 1996 |
ISSN: | 0193-1849 2163-5773 |
Statement of Responsibility: | J. H. Lavin, G. Wittert, W. M. Sun, M. Horowitz, J. E. Morley and N. W. Read |
Abstract: | To investigate the mechanisms by which intestinal carbohydrate affects eating behavior, seven fasted, healthy male volunteers received intraduodenal infusions of glucose or saline over a 90-min period while blood glucose levels were matched by use of intravenous glucose and saline infusions. A second study examined the effect of intraduodenal glucose on eating behavior when the gastrointestinal hormone response was inhibited by intravenous octreotide. Intravenous glucose infusion did not affect hunger or satiety. In contrast, intraduodenal infusion of glucose suppressed hunger, increased fullness and satiety ratings, reduced energy intake, and resulted in higher plasma insulin responses compared with the intravenous glucose infusion. Octreotide abolished the plasma insulin response to intraduodenal glucose and reversed the changes in ratings and eating behavior. This study has shown that the effects of intestinal glucose on appetite are not mediated via an increase in blood glucose but are likely to reflect small intestinal stimulation of release of either insulin or intestinal incretins. |
Keywords: | Duodenum Humans Sodium Chloride Octreotide Gastrointestinal Hormones Carbohydrates Glucose Blood Glucose Injections, Intravenous Intubation, Gastrointestinal Appetite Adult Male |
Description: | Copyright © 1996 by American Physiological Society |
DOI: | 10.1152/ajpendo.1996.271.2.e209 |
Published version: | http://ajpendo.physiology.org/cgi/content/abstract/271/2/E209?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&andorexactfulltext=and&searchid=1&FIRSTINDEX=0&sortspec=relevance&volume=271&firstpage=E209&resourcetype=HWCIT |
Appears in Collections: | Aurora harvest 4 Medicine publications |
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