Please use this identifier to cite or link to this item:
https://hdl.handle.net/2440/86846
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dc.contributor.author | Carter, K. | - |
dc.contributor.author | McCaskie, P. | - |
dc.contributor.author | Palmer, L. | - |
dc.date.issued | 2008 | - |
dc.identifier.citation | BMC Bioinformatics, 2008; 9(1):557-1-557-6 | - |
dc.identifier.issn | 1471-2105 | - |
dc.identifier.issn | 1471-2105 | - |
dc.identifier.uri | http://hdl.handle.net/2440/86846 | - |
dc.description.abstract | Background: Researchers wishing to conduct genetic association analysis involving single nucleotide polymorphisms (SNPs) or haplotypes are often confronted with the lack of user-friendly graphical analysis tools, requiring sophisticated statistical and informatics expertise to perform relatively straightforward tasks. Tools, such as the SimHap package for the R statistics language, provide the necessary statistical operations to conduct sophisticated genetic analysis, but lacks a graphical user interface that allows anyone but a professional statistician to effectively utilise the tool. Results: We have developed SimHap GUI, a cross-platform integrated graphical analysis tool for conducting epidemiological, single SNP and haplotype-based association analysis. SimHap GUI features a novel workflow interface that guides the user through each logical step of the analysis process, making it accessible to both novice and advanced users. This tool provides a seamless interface to the SimHap R package, while providing enhanced functionality such as sophisticated data checking, automated data conversion, and real-time estimations of haplotype simulation progress. Conclusion: SimHap GUI provides a novel, easy-to-use, cross-platform solution for conducting a range of genetic and non-genetic association analyses. This provides a free alternative to commercial statistics packages that is specifically designed for genetic association analysis. | - |
dc.description.statementofresponsibility | Kim W Carter, Pamela A McCaskie, Lyle J Palmer | - |
dc.language.iso | en | - |
dc.publisher | BioMed Central | - |
dc.rights | © 2008 Carter et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | - |
dc.source.uri | http://dx.doi.org/10.1186/1471-2105-9-557 | - |
dc.subject | Haplotypes | - |
dc.subject | Polymorphism, Single Nucleotide | - |
dc.subject | Algorithms | - |
dc.subject | Computer Graphics | - |
dc.subject | Software | - |
dc.subject | Programming Languages | - |
dc.subject | User-Computer Interface | - |
dc.subject | Genome-Wide Association Study | - |
dc.title | SimHap GUI: an intuitive graphical user interface for genetic association analysis | - |
dc.type | Journal article | - |
dc.identifier.doi | 10.1186/1471-2105-9-557 | - |
dc.relation.grant | http://purl.org/au-research/grants/arc/DP0663247 | - |
pubs.publication-status | Published | - |
dc.identifier.orcid | Palmer, L. [0000-0002-1628-3055] | - |
Appears in Collections: | Aurora harvest 7 Translational Health Science publications |
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File | Description | Size | Format | |
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hdl_86846.pdf | Published version | 302.55 kB | Adobe PDF | View/Open |
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