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https://hdl.handle.net/2440/87104
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Type: | Journal article |
Title: | Influenza vaccine effectiveness in Australia: results from the Australian Sentinel Practices Research Network |
Author: | Sullivan, S. Chilver, M. Higgins, G. Cheng, A. Stocks, N. |
Citation: | Medical Journal of Australia, 2014; 201(2):109-111 |
Publisher: | MJA Group Australia |
Issue Date: | 2014 |
ISSN: | 0025-729X 1326-5377 |
Statement of Responsibility: | Sheena G Sullivan, Monique B-N Chilver, Geoff Higgins, Allen C Cheng, Nigel P Stocks |
Abstract: | OBJECTIVE: To estimate influenza vaccine coverage and effectiveness against medically attended laboratory-confirmed influenza for the 2012 season. DESIGN, SETTING AND PARTICIPANTS: Test-negative design involving patients recruited as part of the Australian Sentinel Practices Research Network, a network of sentinel general practitioners throughout Australia. Throughout 2012, at the discretion of the GP at one of 102 participating practices, patients presenting with influenza-like illness were swabbed and included in the study. MAIN OUTCOME MEASURE: Influenza vaccine effectiveness (VE) estimated as (1-OR)*100% by logistic regression. RESULTS: 1775 patients were swabbed. The epidemic period was identified as Weeks 10 to 43 of 2012. After exclusions, there were 1414 patients for the VE analysis, including 593 (42%) who tested influenza-positive and 821 who tested negative. 27% of test-negative patients were vaccinated, of whom most were aged 50 years and over. The overall VE, adjusted for age group, month of presentation and state or territory, was 23% (95% CI, -4% to 43%) against all influenza types, 15% (95% CI, -17% to 38%) against influenza A, 13% (95% CI, -20% to 36%) against influenza A(not H1) and 53% (95% CI, 5% to 77%) against influenza B. CONCLUSION: Vaccination against influenza was modestly protective, reducing the risk of medical presentation with influenza by around 23%. |
Keywords: | Humans Influenza Vaccines Vaccination Sentinel Surveillance Logistic Models Adolescent Adult Aged Aged, 80 and over Middle Aged Child Child, Preschool Infant Australia Female Male Influenza, Human Young Adult General Practice |
Rights: | Copyright status unknown |
DOI: | 10.5694/mja14.00106 |
Published version: | http://dx.doi.org/10.5694/mja14.00106 |
Appears in Collections: | Aurora harvest 2 General Practice publications |
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